CDK5R2

From Wikipedia, the free encyclopedia

Cyclin-dependent kinase 5, regulatory subunit 2 (p39)

Identifiers

CDK5R2; NCK5AI; P39; p39nck5ai

External IDs

OMIM: 603764 MGI: 1330828 HomoloGene: 2924

Gene ontology
Molecular Function:	• cyclin-dependent protein kinase 5 activator activity
Cellular Component:	• cyclin-dependent protein kinase 5 activator complex
Biological Process:	• regulation of cyclin-dependent protein kinase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003936 (mRNA)
NP_003927 (protein)

NM_009872 (mRNA)
NP_034002 (protein)

Location

Chr 2: 219.53 - 219.54 Mb

n/a

Pubmed search

[1]

[2]

Cyclin-dependent kinase 5, regulatory subunit 2 (p39), also known as CDK5R2, is a human gene.^[1]

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39).

[edit] Further reading

Tang D, Yeung J, Lee KY, et al. (1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator.". J. Biol. Chem. 270 (45): 26897-903. PMID 7592934.
Humbert S, Dhavan R, Tsai L (2000). "p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.". J. Cell. Sci. 113 ( Pt 6): 975-83. PMID 10683146.
Humbert S, Lanier LM, Tsai LH (2001). "Synaptic localization of p39, a neuronal activator of cdk5.". Neuroreport 11 (10): 2213-6. PMID 10923673.
Muravenko OV, Gizatullin RZ, Protopopov AI, et al. (2000). "Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization.". Cytogenet. Cell Genet. 89 (3-4): 160-1. PMID 10965112.
Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2.". J. Biol. Chem. 276 (26): 23712-8. doi:10.1074/jbc.M010002200. PMID 11320080.
Patzke H, Tsai LH (2002). "Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.". J. Biol. Chem. 277 (10): 8054-60. doi:10.1074/jbc.M109645200. PMID 11784720.
Dhavan R, Greer PL, Morabito MA, et al. (2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.". J. Neurosci. 22 (18): 7879-91. PMID 12223541.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sakashita G, Shima H, Komatsu M, et al. (2004). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.". J. Biochem. 133 (2): 165-71. PMID 12761178.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Rademakers R, Sleegers K, Theuns J, et al. (2005). "Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.". Neurobiol. Aging 26 (8): 1145-51. doi:10.1016/j.neurobiolaging.2004.10.003. PMID 15917097.