CD3EAP

From Wikipedia, the free encyclopedia

CD3e molecule, epsilon associated protein

Identifiers

CD3EAP; CAST; ASE-1; MGC118851; PAF49

External IDs

OMIM: 107325 MGI: 1917583 HomoloGene: 17107

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• RNA polymerase I transcription factor complex • nucleus • nucleolus • DNA-directed RNA polymerase I complex
Biological Process:	• immune response • transmembrane receptor protein tyrosine kinase signaling pathway • rRNA transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012099 (mRNA)
NP_036231 (protein)

NM_145822 (mRNA)
NP_665821 (protein)

Location

Chr 19: 50.6 - 50.61 Mb

Chr 7: 18.52 - 18.52 Mb

Pubmed search

[1]

[2]

CD3e molecule, epsilon associated protein, also known as CD3EAP, is a human gene.^[1]

[edit] References

^ Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein.

[edit] Further reading

Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes.". Chromosoma 106 (8): 493–502. PMID 9426281.
Yamazaki T, Hamano Y, Tashiro H, et al. (1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells.". J. Biol. Chem. 274 (26): 18173–80. PMID 10373416.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMID 15226435.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Panov KI, Panova TB, Gadal O, et al. (2006). "RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.". Mol. Cell. Biol. 26 (14): 5436–48. doi:10.1128/MCB.00230-06. PMID 16809778.
Skjelbred CF, Saebø M, Nexø BA, et al. (2006). "Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study.". BMC Cancer 6: 175. doi:10.1186/1471-2407-6-175. PMID 16817948.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.