CD180

From Wikipedia, the free encyclopedia

CD180 molecule

Identifiers

CD180; LY64; Ly78; MGC126233; MGC126234; RP105

External IDs

OMIM: 602226 MGI: 1194924 HomoloGene: 4077

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• inflammatory response • innate immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005582 (mRNA)
NP_005573 (protein)

NM_008533 (mRNA)
NP_032559 (protein)

Location

Chr 5: 66.51 - 66.53 Mb

Chr 13: 103.81 - 103.83 Mb

Pubmed search

[1]

[2]

CD180 molecule, also known as CD180, is a human gene.^[1]

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.^[1]

[edit] References

^ ^a ^b Entrez Gene: CD180 CD180 molecule.

[edit] Further reading

Honda Y, Yamagiwa S, Matsuda Y, et al. (2007). "Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis.". J. Hepatol. 47 (3): 404-11. doi:10.1016/j.jhep.2007.03.012. PMID 17448566.
Divanovic S, Trompette A, Atabani SF, et al. (2005). "Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.". Nat. Immunol. 6 (6): 571-8. doi:10.1038/ni1198. PMID 15852007.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191-7. doi:10.1038/nm822. PMID 12539042.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Miura Y, Shimazu R, Miyake K, et al. (1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells.". Blood 92 (8): 2815-22. PMID 9763566.
Miyake K, Shimazu R, Kondo J, et al. (1998). "Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression.". J. Immunol. 161 (3): 1348-53. PMID 9686597.
Miura Y, Miyake K, Yamashita Y, et al. (1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64).". Genomics 38 (3): 299-304. doi:10.1006/geno.1996.0632. PMID 8975706.