CBX8

From Wikipedia, the free encyclopedia

Chromobox homolog 8 (Pc class homolog, Drosophila)

PDB rendering based on 2dnv.

Available structures: 2dnv

Identifiers

Symbol(s)

CBX8; PC3; HPC3; RC1

External IDs

MGI: 1353589 HomoloGene: 32199

Gene ontology
Molecular Function:	• chromatin binding • ubiquitin-protein ligase activity • protein binding
Cellular Component:	• ubiquitin ligase complex • chromatin • nucleus • PcG protein complex
Biological Process:	• chromatin assembly or disassembly • transcription • regulation of transcription, DNA-dependent • chromatin modification • histone ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020649 (mRNA)
NP_065700 (protein)

NM_013926 (mRNA)
NP_038954 (protein)

Location

Chr 17: 75.38 - 75.39 Mb

Chr 11: 118.85 - 118.86 Mb

Pubmed search

[1]

[2]

Chromobox homolog 8 (Pc class homolog, Drosophila), also known as CBX8, is a human gene.^[1]

[edit] References

^ Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila).

[edit] Further reading

Bárdos JI, Saurin AJ, Tissot C, et al. (2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.". Oncogene 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias.". Oncogene 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. PMID 15009096.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Dietrich N, Bracken AP, Trinh E, et al. (2007). "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.". EMBO J. 26 (6): 1637–48. doi:10.1038/sj.emboj.7601632. PMID 17332741.