CBR3

From Wikipedia, the free encyclopedia


Carbonyl reductase 3
PDB rendering based on 2hrb.
Available structures: 2hrb
Identifiers
Symbol(s) CBR3; hCBR3
External IDs OMIM: 603608 MGI: 1309992 HomoloGene: 20332
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 874 109857
Ensembl ENSG00000159231 ENSMUSG00000022947
Uniprot O75828 n/a
Refseq NM_001236 (mRNA)
NP_001227 (protein)		 NM_173047 (mRNA)
NP_766635 (protein)
Location Chr 21: 36.43 - 36.44 Mb Chr 16: 93.57 - 93.58 Mb
Pubmed search [1] [2]

Carbonyl reductase 3, also known as CBR3, is a human gene.[1]

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.[1]

[edit] References

  1. ^ a b Entrez Gene: CBR3 carbonyl reductase 3.

[edit] Further reading

  • Wermuth B, Mäder-Heinemann G, Ernst E (1995). "Cloning and expression of carbonyl reductase from rat testis.". Eur. J. Biochem. 228 (2): 473–9. PMID 7705364. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.". Genomics 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011. 
  • Watanabe K, Sugawara C, Ono A, et al. (1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2.". Genomics 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676. 
  • Ismail E, Al-Mulla F, Tsuchida S, et al. (2000). "Carbonyl reductase: a novel metastasis-modulating function.". Cancer Res. 60 (5): 1173–6. PMID 10728668. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
  • Umemoto M, Yokoyama Y, Sato S, et al. (2001). "Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer.". Br. J. Cancer 85 (7): 1032–6. doi:10.1038/sj.bjc.6692034. PMID 11592776. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Lakhman SS, Ghosh D, Blanco JG (2005). "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3).". Drug Metab. Dispos. 33 (2): 254–7. doi:10.1124/dmd.104.002006. PMID 15537833. 
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