CBLB

From Wikipedia, the free encyclopedia

Cas-Br-M (murine) ecotropic retroviral transforming sequence b

PDB rendering based on 2ooa.

Available structures: 2ooa, 2oob

Identifiers

Symbol(s)

CBLB; DKFZp686J10223; DKFZp779A0729; DKFZp779F1443; FLJ36865; FLJ41152; Nbla00127; RNF56

External IDs

OMIM: 604491 MGI: 2146430 HomoloGene: 15856

Gene ontology
Molecular Function:	• signal transducer activity • calcium ion binding • protein binding • zinc ion binding • ligase activity
Cellular Component:	• nucleus
Biological Process:	• ubiquitin cycle • NLS-bearing substrate import into nucleus • immune response • cell surface receptor linked signal transduction • intracellular signaling cascade • T cell activation • negative regulation of T cell receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_170662 (mRNA)
NP_733762 (protein)

XM_001003161 (mRNA)
XP_001003161 (protein)

Location

Chr 3: 106.86 - 107.07 Mb

n/a

Pubmed search

[1]

[2]

Cas-Br-M (murine) ecotropic retroviral transforming sequence b, also known as CBLB, is a human gene.^[1]

[edit] References

^ Entrez Gene: CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b.

[edit] Further reading

Fang N, Fang D, Wang HY, et al. (2002). "Regulation of immune responses by E3 ubiquitin-protein ligases.". Curr. Dir. Autoimmun. 5: 161–75. PMID 11826757.
Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.". Cancer Lett. 197 (1-2): 63–8. PMID 12880961.
Keane MM, Rivero-Lezcano OM, Mitchell JA, et al. (1995). "Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.". Oncogene 10 (12): 2367–77. PMID 7784085.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Bustelo XR, Crespo P, López-Barahona M, et al. (1997). "Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.". Oncogene 15 (21): 2511–20. PMID 9399639.
Lavagna-Sévenier C, Marchetto S, Birnbaum D, Rosnet O (1998). "The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells.". J. Biol. Chem. 273 (24): 14962–7. PMID 9614102.
Elly C, Witte S, Zhang Z, et al. (1999). "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.". Oncogene 18 (5): 1147–56. doi:10.1038/sj.onc.1202411. PMID 10022120.
Zhang Z, Elly C, Qiu L, et al. (1999). "A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.". Curr. Biol. 9 (4): 203–6. PMID 10074432.
Ettenberg SA, Keane MM, Nau MM, et al. (1999). "cbl-b inhibits epidermal growth factor receptor signaling.". Oncogene 18 (10): 1855–66. doi:10.1038/sj.onc.1202499. PMID 10086340.
Wong ES, Lim J, Low BC, et al. (2001). "Evidence for direct interaction between Sprouty and Cbl.". J. Biol. Chem. 276 (8): 5866–75. doi:10.1074/jbc.M006945200. PMID 11053437.
Fang D, Wang HY, Fang N, et al. (2001). "Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.". J. Biol. Chem. 276 (7): 4872–8. doi:10.1074/jbc.M008901200. PMID 11087752.
Ettenberg SA, Magnifico A, Cuello M, et al. (2001). "Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex.". J. Biol. Chem. 276 (29): 27677–84. doi:10.1074/jbc.M102641200. PMID 11375397.
Arron JR, Vologodskaia M, Wong BR, et al. (2001). "A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.". J. Biol. Chem. 276 (32): 30011–7. doi:10.1074/jbc.M100414200. PMID 11406619.
Fang D, Liu YC (2001). "Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.". Nat. Immunol. 2 (9): 870–5. doi:10.1038/ni0901-870. PMID 11526404.
Sattler M, Pride YB, Quinnan LR, et al. (2002). "Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.". Oncogene 21 (9): 1423–33. doi:10.1038/sj.onc.1205202. PMID 11857085.
Yasuda T, Tezuka T, Maeda A, et al. (2002). "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells.". J. Exp. Med. 196 (1): 51–63. PMID 12093870.
Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191–6. doi:10.1073/pnas.192462299. PMID 12218189.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.