Carnitine O-octanoyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a carnitine O-octanoyltransferase (EC 2.3.1.137) is an enzyme that catalyzes the chemical reaction

octanoyl-CoA + L-carnitine $\rightleftharpoons$ CoA + L-octanoylcarnitine

Thus, the two substrates of this enzyme are octanoyl-CoA and L-carnitine, whereas its two products are CoA and L-octanoylcarnitine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is octanoyl-CoA:L-carnitine O-octanoyltransferase. Other names in common use include medium-chain/long-chain carnitine acyltransferase, carnitine medium-chain acyltransferase, easily solubilized mitochondrial carnitine palmitoyltransferase, and overt mitochondrial carnitine palmitoyltransferase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XL7, 1XL8, 1XMC, and 1XMD.

[edit] References

IUBMB entry for 2.3.1.137
BRENDA references for 2.3.1.137 (Recommended.)
PubMed references for 2.3.1.137
PubMed Central references for 2.3.1.137
Google Scholar references for 2.3.1.137
Farrell SO, Fiol CJ, Reddy JK, Bieber LL (1984). "Properties of purified carnitine acyltransferases of mouse liver peroxisomes". J. Biol. Chem. 259: 13089–95. PMID 6436243.
Healy MJ, Kerner J, Bieber LL (1988). "Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?". Biochem. J. 249: 231–7. PMID 3342008.
Miyazawa S, Ozasa H, Osumi T, Hashimoto T (Tokyo). "Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver". J. Biochem.: 529–42. PMID 6630173.