Carnitine O-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a carnitine O-acetyltransferase (EC 2.3.1.7) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + carnitine $\rightleftharpoons$ CoA + O-acetylcarnitine

Thus, the two substrates of this enzyme are acetyl-CoA and carnitine, whereas its two products are CoA and O-acetylcarnitine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:carnitine O-acetyltransferase. Other names in common use include acetyl-CoA-carnitine O-acetyltransferase, acetylcarnitine transferase, carnitine acetyl coenzyme A transferase, carnitine acetylase, carnitine acetyltransferase, carnitine-acetyl-CoA transferase, and CATC. This enzyme participates in alanine and aspartate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1NDB, 1NDF, 1NDI, 1NM8, 1S5O, 1T7O, and 1T7Q.

[edit] References

IUBMB entry for 2.3.1.7
BRENDA references for 2.3.1.7 (Recommended.)
PubMed references for 2.3.1.7
PubMed Central references for 2.3.1.7
Google Scholar references for 2.3.1.7
Chase JFA, Pearson DJ and Tubbs PK (1965). "The preparation of crystalline carnitine acetyltransferase". Biochim. Biophys. Acta 96: 162–165.
FRIEDMAN S, FRAENKEL G (1955). "Reversible enzymatic acetylation of carnitine". Arch. Biochem. Biophys. 59: 491–501. doi:10.1016/0003-9861(55)90515-4. PMID 13275966.
Miyazawa S, Ozasa H, Furuta S, Osumi T and Hashimoto T (Tokyo). "Purification and properties of carnitine acetyl transferase from rat liver". J. Biochem.: 439–451.