Carboxylate reductase

From Wikipedia, the free encyclopedia

In enzymology, a carboxylate reductase (EC 1.2.99.6) is an enzyme that catalyzes the chemical reaction

an aldehyde + acceptor + H₂O a carboxylate + reduced acceptor

The 3 substrates of this enzyme are aldehyde, acceptor, and H₂O, whereas its two products are carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with other acceptors. The systematic name of this enzyme class is aldehyde:acceptor oxidoreductase. This enzyme is also called aldehyde:(acceptor) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, tungsten.

[edit] References

• IUBMB entry for 1.2.99.6
• BRENDA references for 1.2.99.6 (Recommended.)
• PubMed references for 1.2.99.6
• PubMed Central references for 1.2.99.6
• Google Scholar references for 1.2.99.6
• White H, Strobl G, Feicht R, Simon H (1989). "Carboxylic acid reductase: a new tungsten enzyme catalyses the reduction of non-activated carboxylic acids to aldehydes". Eur. J. Biochem. 184: 89–96. doi:10.1111/j.1432-1033.1989.tb14993.x. PMID 2550230. 

[edit] External links

The CAS registry number for this enzyme class is 125008-36-8.

• IUBMB entry for 1.2.99.6

• KEGG entry for 1.2.99.6

• BRENDA entry for 1.2.99.6

• NiceZyme view of 1.2.99.6

• EC2PDB: PDB structures for 1.2.99.6

• PRIAM entry for 1.2.99.6

• PUMA2 entry for 1.2.99.6

• IntEnz: Integrated Enzyme entry for 1.2.99.6

• MetaCyc entry for 1.2.99.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047770: carboxylate reductase

• AMIGO entry for GO code 0047770: carboxylate reductase