Carboxy-cis,cis-muconate cyclase

From Wikipedia, the free encyclopedia

In enzymology, a carboxy-cis,cis-muconate cyclase (EC 5.5.1.5) is an enzyme that catalyzes the chemical reaction

3-carboxy-2,5-dihydro-5-oxofuran-2-acetate 3-carboxy-cis,cis-muconate

Hence, this enzyme has one substrate, 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate, and one product, 3-carboxy-cis,cis-muconate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). This enzyme is also called 3-carboxymuconate cyclase. This enzyme participates in benzoate degradation via hydroxylation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1JOF.

[edit] References

• IUBMB entry for 5.5.1.5
• BRENDA references for 5.5.1.5 (Recommended.)
• PubMed references for 5.5.1.5
• PubMed Central references for 5.5.1.5
• Google Scholar references for 5.5.1.5
• GROSS SR, GAFFORD RD, TATUM EL (1956). "The metabolism of protocatechuic acid by Neurospora". J. Biol. Chem. 219: 781–96. PMID 13319299. 

[edit] External links

The CAS registry number for this enzyme class is 37318-55-1.

• IUBMB entry for 5.5.1.5

• KEGG entry for 5.5.1.5

• BRENDA entry for 5.5.1.5

• NiceZyme view of 5.5.1.5

• EC2PDB: PDB structures for 5.5.1.5

• PRIAM entry for 5.5.1.5

• PUMA2 entry for 5.5.1.5

• IntEnz: Integrated Enzyme entry for 5.5.1.5

• MetaCyc entry for 5.5.1.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047768: carboxy-cis,cis-muconate cyclase

• AMIGO entry for GO code 0047768: carboxy-cis,cis-muconate cyclase