Carbamoyl-serine ammonia-lyase

From Wikipedia, the free encyclopedia

In enzymology, a carbamoyl-serine ammonia-lyase (EC 4.3.1.13) is an enzyme that catalyzes the chemical reaction

O-carbamoyl-L-serine + H₂O pyruvate + 2 NH₃ + CO₂

Thus, the two substrates of this enzyme are O-carbamoyl-L-serine and H₂O, whereas its 3 products are pyruvate, NH₃, and CO₂.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is O-carbamoyl-L-serine ammonia-lyase (decarboxylating pyruvate-forming). Other names in common use include O-carbamoyl-L-serine deaminase, carbamoylserine deaminase, and O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming). It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.3.1.13
• BRENDA references for 4.3.1.13 (Recommended.)
• PubMed references for 4.3.1.13
• PubMed Central references for 4.3.1.13
• Google Scholar references for 4.3.1.13
• Copper AJ, Meister A (1973). "Enzymatic conversion of O-carbamyl-L-serine to pyruvate and ammonia". Biochem. Biophys. Res. Commun. 55: 780–7. doi:10.1016/0006-291X(73)91212-6. PMID 4761084. 

[edit] External links

The CAS registry number for this enzyme class is 52227-64-2.

• IUBMB entry for 4.3.1.13

• KEGG entry for 4.3.1.13

• BRENDA entry for 4.3.1.13

• NiceZyme view of 4.3.1.13

• EC2PDB: PDB structures for 4.3.1.13

• PRIAM entry for 4.3.1.13

• PUMA2 entry for 4.3.1.13

• IntEnz: Integrated Enzyme entry for 4.3.1.13

• MetaCyc entry for 4.3.1.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047766: carbamoyl-serine ammonia-lyase

• AMIGO entry for GO code 0047766: carbamoyl-serine ammonia-lyase