CAPN9

From Wikipedia, the free encyclopedia

Calpain 9

PDB rendering based on 1ziv.

Available structures: 1ziv, 2p0r

Identifiers

Symbol(s)

CAPN9; GC36; nCL-4

External IDs

OMIM: 606401 MGI: 1920897 HomoloGene: 38208

Gene ontology
Molecular Function:	• calpain activity • calcium ion binding
Cellular Component:	• cellular_component • intracellular
Biological Process:	• proteolysis • digestion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006615 (mRNA)
NP_006606 (protein)

XM_001002268 (mRNA)
XP_001002268 (protein)

Location

Chr 1: 228.95 - 229 Mb

n/a

Pubmed search

[1]

[2]

Calpain 9, also known as CAPN9, is a human gene.^[1]

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAPN9 calpain 9.

[edit] Further reading

Huang Y, Wang KK (2001). "The calpain family and human disease.". Trends in molecular medicine 7 (8): 355-62. PMID 11516996.
Suzuki K, Sorimachi H, Yoshizawa T, et al. (1996). "Calpain: novel family members, activation, and physiologic function.". Biol. Chem. Hoppe-Seyler 376 (9): 523-9. PMID 8561910.
Davis TL, Walker JR, Finerty PJ, et al. (2007). "The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.". J. Mol. Biol. 366 (1): 216-29. doi:10.1016/j.jmb.2006.11.037. PMID 17157313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yoshikawa Y, Mukai H, Hino F, et al. (2000). "Isolation of two novel genes, down-regulated in gastric cancer.". Jpn. J. Cancer Res. 91 (5): 459-63. PMID 10835488.
Lee HJ, Tomioka S, Kinbara K, et al. (1999). "Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system.". Arch. Biochem. Biophys. 362 (1): 22-31. doi:10.1006/abbi.1998.1021. PMID 9917325.
Lee HJ, Sorimachi H, Jeong SY, et al. (1998). "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract.". Biol. Chem. 379 (2): 175-83. PMID 9524069.