CAPG

From Wikipedia, the free encyclopedia

Capping protein (actin filament), gelsolin-like

PDB rendering based on 1j72.

Available structures: 1j72, 1jhw

Identifiers

Symbol(s)

CAPG; AFCP; MCP

External IDs

OMIM: 153615 MGI: 1098259 HomoloGene: 37523

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• nucleus • F-actin capping protein complex
Biological Process:	• protein complex assembly • cell projection biogenesis • barbed-end actin filament capping

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001747 (mRNA)
NP_001738 (protein)

XM_974489 (mRNA)
XP_979583 (protein)

Location

Chr 2: 85.48 - 85.49 Mb

Chr 6: 72.48 - 72.49 Mb

Pubmed search

[1]

[2]

Capping protein (actin filament), gelsolin-like, also known as CAPG, is a human gene.^[1]

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAPG capping protein (actin filament), gelsolin-like.

[edit] Further reading

Dabiri GA, Young CL, Rosenbloom J, Southwick FS (1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.". J. Biol. Chem. 267 (23): 16545-52. PMID 1322908.
Southwick FS (1995). "Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.". J. Biol. Chem. 270 (1): 45-8. PMID 7814409.
Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS (1995). "The human actin-regulatory protein cap G: gene structure and chromosome location.". Genomics 23 (3): 560-5. doi:10.1006/geno.1994.1543. PMID 7851883.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein.". Cell 89 (4): 511-21. PMID 9160743.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Cabello OA, Eliseeva E, He WG, et al. (2002). "Cell cycle-dependent expression and nucleolar localization of hCAP-H.". Mol. Biol. Cell 12 (11): 3527-37. PMID 11694586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Van Impe K, De Corte V, Eichinger L, et al. (2003). "The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.". J. Biol. Chem. 278 (20): 17945-52. doi:10.1074/jbc.M209946200. PMID 12637565.
Pellieux C, Desgeorges A, Pigeon CH, et al. (2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress.". J. Biol. Chem. 278 (31): 29136-44. doi:10.1074/jbc.M300598200. PMID 12754261.
De Corte V, Van Impe K, Bruyneel E, et al. (2005). "Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion.". J. Cell. Sci. 117 (Pt 22): 5283-92. doi:10.1242/jcs.01410. PMID 15454578.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Watari A, Takaki K, Higashiyama S, et al. (2007). "Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG.". Oncogene 25 (56): 7373-80. doi:10.1038/sj.onc.1209732. PMID 16767159.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135-44. doi:10.1021/pr060363j. PMID 17081065.