CAP1

From Wikipedia, the free encyclopedia

CAP, adenylate cyclase-associated protein 1 (yeast)

PDB rendering based on 1k8f.

Available structures: 1k8f

Identifiers

Symbol(s)

CAP1; CAP; CAP1-PEN

External IDs

MGI: 88262 HomoloGene: 74572

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• cytoplasm • membrane • cortical actin cytoskeleton
Biological Process:	• ameboidal cell migration • receptor-mediated endocytosis • establishment and/or maintenance of cell polarity • signal transduction • adenylate cyclase activation • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006367 (mRNA)
NP_006358 (protein)

NM_007598 (mRNA)
NP_031624 (protein)

Location

Chr 1: 40.28 - 40.31 Mb

Chr 4: 122.36 - 122.39 Mb

Pubmed search

[1]

[2]

CAP, adenylate cyclase-associated protein 1 (yeast), also known as CAP1, is a human gene.^[1]

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAP1 CAP, adenylate cyclase-associated protein 1 (yeast).

[edit] Further reading

Matviw H, Yu G, Young D (1992). "Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase-associated CAP proteins.". Mol. Cell. Biol. 12 (11): 5033–40. PMID 1406678.
Yu G, Swiston J, Young D (1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins.". J. Cell. Sci. 107 ( Pt 6): 1671–8. PMID 7962207.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Hubberstey A, Yu G, Loewith R, et al. (1997). "Mammalian CAP interacts with CAP, CAP2, and actin.". J. Cell. Biochem. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Moriyama K, Yahara I (2003). "Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover.". J. Cell. Sci. 115 (Pt 8): 1591–601. PMID 11950878.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dodatko T, Fedorov AA, Grynberg M, et al. (2004). "Crystal structure of the actin binding domain of the cyclase-associated protein.". Biochemistry 43 (33): 10628–41. doi:10.1021/bi049071r. PMID 15311924.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork.". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F. "Phosphoproteomic analysis of the human pituitary.". Pituitary 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684.
Garewal G, Das R, Awasthi A, et al. (2007). "The clinical significance of the spectrum of interactions of CAP+1 (A-->C), a silent beta-globin gene mutation, with other beta-thalassemia mutations and globin gene modifiers in north Indians.". Eur. J. Haematol. 79 (5): 417–21. doi:10.1111/j.1600-0609.2007.00958.x. PMID 17900295.