Talk:Cannabidiol

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Contents

[edit] Removed myths section

I have removed the following text from the article. Cacycle 09:18, 12 October 2005 (UTC)

== Cannabidiol Myths and research==
* Myths|CBD}
*There is a myth, that this substance: Cannabidiol or also named CBD,increase the atention of certain individual(s) when is consume ingested or smoked because Cannabis have certain levels of this substance, CBD,there are many studies that they are not accurate, but please extend this article about cannabidiol.
how can extract cannabidiol?.expand it
*(Apología del cannabis) is a book aclaims that (canabidiol) increase the certain level of attention on the sinapsis of the Brain and senses of the human body. ex.,point of view and object,idea,thingh,senses,The maximus peak of concentration depends on the individual or many variables,such indoors and outdoors other factors ex.Stay on focus on one color or object, for long periods...
With out other interuptions such other ideas sounds ex i have a crayon blue,then i search or imagine , for the origin of the crayon blue color.
There is a certain balance of what we call menthal concentartion,probably a stage of thebrain implies functions in the sinaptical conections of certainneurotransmitters ex. ,Anadamide a neurotransmitter subtance that provoces or cause tranquility state of mind and body , anandamimide derivates from the lenguage sanscrit word Ananda, the guys or individuals who discover and aislate or extact, this substance anandamide ,put the name of the Budism Goddes of tranquility means a goddes from BEATITUD in "SPANISH" , lenguage beatitud have many meanings in ENGLISH lenguage, such as peacefull,tranquility,calm.
(CBD)deliberates the accurate concentartion besides other possibilities of interruption,the substance of Cannabidiol increase the concentration.(this depends on the type of Cannabis Indica], Cannabis Sattiva or Cannabis Ruderalis.and of course the amount of LD50, body mass,and many factors such dosification mg/mass.Also aclaims that the effect is more potentand have a lenght prolongative state if it is consume via oral .
Cannabinol}see also

[edit] Antipsychotic

Cannabidiol has exhibited antipsychotic effects in recent studies. If CBD has an antipsychotic effect, how can it not be considered psychoactive? --Thoric 22:01, 7 June 2006 (UTC)

Caffiene is a psychoactive, it won't make you go loopy. The psycho part of psychoactive does not refer to a possibility of psychosis. I'm not a professional though. JHJPDJKDKHI! 15:07, 4 May 2007 (UTC)
I wasn't implying that psychoactive meant makes you go crazy. What I'm saying is that since antipsychotics are psychoactive, and also since CBD has been shown to have antipsychotic effects, then how can we be sure that CBD is not a psychoactive drug? --Thoric 18:57, 26 June 2007 (UTC)
As far as I can tell, you are both arguing for the same thing. Some folks do seem to think that "psychoactive" equates to a euphoriant or hallucinogenic drug, something that feels good or makes you loco. This may be neither, but that has nothing to do with being a psychoactie drug.

it only exhibits it's antipsychotic effect when THC is present so it is not pshchoactive on it's own. (82.47.164.103 05:30, 11 October 2007 (UTC))

Not true. Studies have been done comparing cannabidiol to other antipsychotic drugs in patients that require antipsychotics (and are not cannabis users). --Thoric 14:22, 11 October 2007 (UTC)

I was popping in just to say the same thing. The article currently reads: "Medically, it appears to relieve convulsion, inflammation, anxiety, and nausea, and to inhibit cancer cell growth[5]. Recent studies have shown cannabidiol to be as effective as atypical antipsychotics in treating schizophrenia.[6]" If the drug reduced anxiety and is an effective antipsychotic, then it is indeed a psychoactive drug. It may not have any use as a recreational substance, a euphoriant, or a psychedelic, but the word is compeltely incorrect. I suggest we change the wording to something saying that it isn't responsible for most of Cannabis's effects, that it doesn't have the effects d9-THC does, that it is not a recreational drug, doesn't cause abuse, etc. Some of these are better than others, obviously, but an unverified induction is better than an something that is completely incorrect, and that evidence to support that is producible. Since there hasn't been discussion on this for a while, I'm just going to strike that part, because I think the rest of the article gives deatils enough to make sense until a decision can be made. --Revaaron (talk) 17:41, 21 December 2007 (UTC)

[edit] Problems with citation

Hey, folks. I've never done a citation before, and couldn't figure it out. Would someone here mind fixing mine, and letting me know what you did? Thanks! --tgeller 02:53, 3 January 2007 (UTC)

Your syntax was correct, it just needed a reference heading and the {{reflist}} template. --Howrealisreal 03:37, 3 January 2007 (UTC)

[edit] Indica not sativa

I thought it was cannabis indica not sativa that had the most cannabidiols. JHJPDJKDKHI! 15:37, 1 May 2007 (UTC)

me too, more cbd than thc in indica and the other way around in satvia. indica makes you 'stoned' and satvia makes you 'high' thats what i thought

[edit] is CBD scheduled?

Is it unscheduled in the US or is it a CI (Schedule I substance) ? On this wiki page it doesn't say anything, but I have seen Cannabidiol listed as Schedule I just can't remember where, CBD isn't listed on http://www.cnsm.csulb.edu/services/safety/druglist.htm but that site may be outdated. So i'm confused, any help?

also this is the most updated GOVERNMENT site listing all scheduled drugs and i dont see CBD listed http://www.access.gpo.gov/nara/cfr/waisidx_01/21cfr1308_01.html

Aa far as I know, it is not scheduled anywhere, but it might be a regulated precursor compound. Cacycle 13:38, 13 June 2007 (UTC)

I wonder if it has been synthetised

[edit] 3D ball structure

Is this the real structure from the article where the crystal structure was published? If not we should remove it because it is misleading or in the best case just a nice picture without any use. -- Panoramix303 21:13, 3 December 2007 (UTC)

It's the crystal structure, from P. G. Jones, L. Falvello, O. Kennard, G. M. Sheldrick and R. Mechoulam (1977). "Cannabidiol". Acta Crystallographica Section B 33: 3211-3214. doi:10.1107/S0567740877010577. 
Ben (talk) 02:08, 14 March 2008 (UTC)

Thanks for the reply and good work! -- Panoramix303 (talk) 10:44, 14 March 2008 (UTC)

[edit] Ligresti antitumor mechanism claim

Ligresti et al suggest that "cannabidiol exerts its effects on [cancer] cells through a combination of mechanisms that include either direct or indirect activation of CB2 and TRPV1 receptors, and induction of oxidative stress, all contributing to induce apoptosis." (emphasis added) - yet Thomas et al show cannabidiol to be a CB2 inverse agonist mouse whole-brain or CHO cell membranes. Ligresti et al's reasoning is that cannabidiol inhibits anandamide inactivation, thus "indirectly activating" CB1/CB2, but I would think the receptor-independent inverse agonist effect would largely negate any action this might have; indeed, they found that "pure agonists" were less effective than CBD, which doesn't seem consistent with an eCB mechanism. Thoughts? St3vo 06:32, 4 December 2007 (UTC)

Leave as it is as no one knows it exactly at the moment. There will be 1 or 2 papers explaining the mechanism in a few months.

-- Panoramix303 07:51, 4 December 2007 (UTC)

Of course. I was just wondering if anyone had any insight into this seeming contradiction that I was missing since cancer isn't my field.St3vo 13:25, 4 December 2007 (UTC)

[edit] Grammar Edit

"Cannabidiol, also known as CBD, cannabinoid found in Cannabis."
This is a fragment with just two subjects.
I will change to "Cannabidiol, also known as CBD, is a cannabinoid found in Cannabis."
Ben-G