CANT1

From Wikipedia, the free encyclopedia

Calcium activated nucleotidase 1

PDB rendering based on 1s18.

Available structures: 1s18, 1s1d, 2h2n, 2h2u

Identifiers

Symbol(s)

CANT1; SCAN-1; SHAPY

External IDs

MGI: 1923275 HomoloGene: 69460

Gene ontology
Molecular Function:	• signal transducer activity • calcium ion binding • hydrolase activity • nucleoside-diphosphatase activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_138793 (mRNA)
NP_620148 (protein)

NM_001025617 (mRNA)
NP_001020788 (protein)

Location

Chr 17: 74.5 - 74.52 Mb

Chr 11: 118.22 - 118.24 Mb

Pubmed search

[1]

[2]

Calcium activated nucleotidase 1, also known as CANT1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CANT1 calcium activated nucleotidase 1.

[edit] Further reading

Failer BU, Braun N, Zimmermann H (2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase.". J. Biol. Chem. 277 (40): 36978–86. doi:10.1074/jbc.M201656200. PMID 12167635.
Smith TM, Hicks-Berger CA, Kim S, Kirley TL (2002). "Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases.". Arch. Biochem. Biophys. 406 (1): 105–15. PMID 12234496.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Murphy DM, Ivanenkov VV, Kirley TL (2003). "Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase.". Biochemistry 42 (8): 2412–21. doi:10.1021/bi026763b. PMID 12600208.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dai J, Liu J, Deng Y, et al. (2004). "Structure and protein design of a human platelet function inhibitor.". Cell 116 (5): 649–59. PMID 15006348.
Yang M, Kirley TL (2004). "Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change.". Biochemistry 43 (28): 9185–94. doi:10.1021/bi049565o. PMID 15248776.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.