CA5B

From Wikipedia, the free encyclopedia

Carbonic anhydrase VB, mitochondrial

Identifiers

CA5B; CA-VB; MGC39962

External IDs

OMIM: 300230 MGI: 1926249 HomoloGene: 21413

Gene ontology
Molecular Function:	• carbonate dehydratase activity • zinc ion binding • lyase activity • metal ion binding
Cellular Component:	• mitochondrion
Biological Process:	• one-carbon compound metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007220 (mRNA)
NP_009151 (protein)

NM_019513 (mRNA)
NP_062386 (protein)

Location

Chr X: 15.67 - 15.71 Mb

Chr X: 159.32 - 159.37 Mb

Pubmed search

[1]

[2]

Carbonic anhydrase VB, mitochondrial, also known as CA5B, is a human gene.^[1]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.^[1]

[edit] References

^ ^a ^b Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial.

[edit] Further reading

Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies.". Annu. Rev. Biochem. 64: 375-401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas.". Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 33 (1): 68-74. PMID 11303978.
Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (1999). "Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x.". J. Biol. Chem. 274 (30): 21228-33. PMID 10409679.
Shah GN, Hewett-Emmett D, Grubb JH, et al. (2000). "Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles.". Proc. Natl. Acad. Sci. U.S.A. 97 (4): 1677-82. PMID 10677517.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Vullo D, Nishimori I, Innocenti A, et al. (2007). "Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.". Bioorg. Med. Chem. Lett. 17 (5): 1336-40. doi:10.1016/j.bmcl.2006.11.075. PMID 17174092.