C1R (gene)

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Complement component 1, r subcomponent
PDB rendering based on 1apq.
Available structures: 1apq, 1gpz, 1md7, 1md8
Identifiers
Symbol(s) C1R;
External IDs OMIM: 216950 MGI: 1355313 HomoloGene: 1313
Orthologs
Human Mouse
Entrez 715 50909


Refseq NM_001733 (mRNA)
NP_001724 (protein)		 XM_001005373 (mRNA)
XP_001005373 (protein)
Pubmed search [1] [2]

Complement component 1, r subcomponent, also known as C1R, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: C1R complement component 1, r subcomponent.

[edit] Further reading

  • Lee SL, Wallace SL, Barone R, et al. (1979). "Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease.". Arthritis Rheum. 21 (8): 958–67. PMID 737019. 
  • Ward SL, Ingham KC (1992). "A calcium-binding monoclonal antibody that recognizes a non-calcium-binding epitope in the short consensus repeat units (SCRs) of complement C1r.". Mol. Immunol. 29 (1): 83–93. PMID 1370572. 
  • Luo C, Thielens NM, Gagnon J, et al. (1992). "Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex.". Biochemistry 31 (17): 4254–62. PMID 1533159. 
  • Busby TF, Ingham KC (1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q.". Biochemistry 29 (19): 4613–8. PMID 2372546. 
  • Lyons LA, Kamboh MI, Ferrell RE (1989). "Genetic studies of low-abundance human plasma proteins. XI. Linkage analysis and population genetics of the C1S subcomponent of the first complement component.". Complement and inflammation 6 (2): 81–7. PMID 2541966. 
  • Arlaud GJ, Van Dorsselaer A, Bell A, et al. (1987). "Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r.". FEBS Lett. 222 (1): 129–34. PMID 2820791. 
  • Nguyen VC, Tosi M, Gross MS, et al. (1988). "Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13.". Hum. Genet. 78 (4): 363–8. PMID 2834284. 
  • Leytus SP, Kurachi K, Sakariassen KS, Davie EW (1986). "Nucleotide sequence of the cDNA coding for human complement C1r.". Biochemistry 25 (17): 4855–63. PMID 3021205. 
  • Journet A, Tosi M (1987). "Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r.". Biochem. J. 240 (3): 783–7. PMID 3030286. 
  • Arlaud GJ, Willis AC, Gagnon J (1987). "Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.". Biochem. J. 241 (3): 711–20. PMID 3036070. 
  • Chesne S, Villiers CL, Arlaud GJ, et al. (1982). "Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1.". Biochem. J. 201 (1): 61–70. PMID 6282262. 
  • Arlaud GJ, Gagnon J (1983). "Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r.". Biochemistry 22 (8): 1758–64. PMID 6303394. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Nöthen MM, Dewald G (1994). "A common amino acid polymorphism in complement component C1R.". Hum. Mol. Genet. 3 (1): 217. PMID 8162045. 
  • Gasque P, Ischenko A, Legoedec J, et al. (1993). "Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells.". J. Biol. Chem. 268 (33): 25068–74. PMID 8227070. 
  • Pelloux S, Thielens NM, Hudry-Clergeon G, et al. (1996). "Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.". FEBS Lett. 386 (1): 15–20. PMID 8635594. 
  • Bradley K, North J, Saunders D, et al. (1996). "Synthesis of classical pathway complement components by chondrocytes.". Immunology 88 (4): 648–56. PMID 8881771. 
  • Lacroix M, Rossi V, Gaboriaud C, et al. (1997). "Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.". Biochemistry 36 (21): 6270–82. doi:10.1021/bi962719i. PMID 9174342. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Bersch B, Hernandez JF, Marion D, Arlaud GJ (1998). "Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family.". Biochemistry 37 (5): 1204–14. doi:10.1021/bi971851v. PMID 9477945. 
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