C12orf5

From Wikipedia, the free encyclopedia


Chromosome 12 open reading frame 5
Identifiers
Symbol(s) C12orf5; TIGAR
External IDs OMIM: 610775 MGI: 2442752 HomoloGene: 32473
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57103 319801
Ensembl ENSG00000078237 n/a
Uniprot Q9NQ88 n/a
Refseq NM_020375 (mRNA)
NP_065108 (protein)		 NM_177003 (mRNA)
NP_795977 (protein)
Location Chr 12: 4.3 - 4.33 Mb n/a
Pubmed search [1] [2]

Chromosome 12 open reading frame 5, also known as C12orf5, is a human gene.[1]

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.[1]

[edit] References

  1. ^ a b Entrez Gene: C12orf5 chromosome 12 open reading frame 5.

[edit] Further reading

  • Green DR, Chipuk JE (2006). "p53 and metabolism: Inside the TIGAR.". Cell 126 (1): 30–2. doi:10.1016/j.cell.2006.06.032. PMID 16839873. 
  • "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23." (2000). Nat. Genet. 26 (3): 345–8. doi:10.1038/81664. PMID 11062477. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Katoh Y, Katoh M (2005). "Comparative genomics on mammalian Fgf6-Fgf23 locus.". Int. J. Mol. Med. 16 (2): 355–8. PMID 16012775. 
  • Jen KY, Cheung VG (2005). "Identification of novel p53 target genes in ionizing radiation response.". Cancer Res. 65 (17): 7666–73. doi:10.1158/0008-5472.CAN-05-1039. PMID 16140933. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Bensaad K, Tsuruta A, Selak MA, et al. (2006). "TIGAR, a p53-inducible regulator of glycolysis and apoptosis.". Cell 126 (1): 107–20. doi:10.1016/j.cell.2006.05.036. PMID 16839880. 
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