C11orf30

From Wikipedia, the free encyclopedia

Chromosome 11 open reading frame 30

PDB rendering based on 1utu.

Available structures: 1utu, 1uz3, 2fmm

Identifiers

Symbol(s)

C11orf30; EMSY; FLJ90741; GL002

External IDs

OMIM: 608573 MGI: 1924203 HomoloGene: 32465

Gene ontology
Cellular Component:	• nucleus
Biological Process:	• DNA repair • transcription • regulation of transcription, DNA-dependent • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020193 (mRNA)
NP_064578 (protein)

XM_897335 (mRNA)
XP_902428 (protein)

Location

Chr 11: 75.83 - 75.94 Mb

Chr 7: 98.47 - 98.53 Mb

Pubmed search

[1]

[2]

Chromosome 11 open reading frame 30, also known as C11orf30, is a human gene.^[1]

[edit] References

^ Entrez Gene: C11orf30 chromosome 11 open reading frame 30.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hughes-Davies L, Huntsman D, Ruas M, et al. (2004). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.". Cell 115 (5): 523-35. PMID 14651845.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bera TK, Das S, Maeda H, et al. (2004). "NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 3059-64. doi:10.1073/pnas.0308746101. PMID 14981236.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ekblad CM, Chavali GB, Basu BP, et al. (2005). "Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.". EMBO Rep. 6 (7): 675-80. doi:10.1038/sj.embor.7400415. PMID 15947784.
Chavali GB, Ekblad CM, Basu BP, et al. (2005). "Crystal structure of the ENT domain of human EMSY.". J. Mol. Biol. 350 (5): 964-73. doi:10.1016/j.jmb.2005.05.047. PMID 15978617.
Benusiglio PR, Lesueur F, Luccarini C, et al. (2006). "Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs.". BMC Cancer 5: 81. doi:10.1186/1471-2407-5-81. PMID 16029503.
Raouf A, Brown L, Vrcelj N, et al. (2005). "Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY.". J. Natl. Cancer Inst. 97 (17): 1302-6. doi:10.1093/jnci/dji254. PMID 16145051.
Brown LA, Irving J, Parker R, et al. (2006). "Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas.". Gynecol. Oncol. 100 (2): 264-70. doi:10.1016/j.ygyno.2005.08.026. PMID 16236351.
Huang Y, Myers MP, Xu RM (2006). "Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding.". Structure 14 (4): 703-12. doi:10.1016/j.str.2006.01.007. PMID 16615912.