C-src tyrosine kinase

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C-src tyrosine kinase
PDB rendering based on 1byg.
Available structures: 1byg, 1csk, 1jeg, 1k9a
Identifiers
Symbol(s)	CSK; MGC117393
External IDs	OMIM: 124095 MGI: 88537 HomoloGene: 55818
Gene ontology Molecular Function: • nucleotide binding • protein-tyrosine kinase activity • ATP binding • protein C-terminus binding • transferase activity Cellular Component: • cytoplasm • plasma membrane • intercellular junction Biological Process: • regulation of progression through cell cycle • protein amino acid phosphorylation • intracellular signaling cascade • negative regulation of cell proliferation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1445	12988
Ensembl	ENSG00000103653	ENSMUSG00000032312
Uniprot	P41240	Q3UVH2
Refseq	NM_004383 (mRNA) NP_004374 (protein)	NM_007783 (mRNA) NP_031809 (protein)
Location	Chr 15: 72.86 - 72.88 Mb	Chr 9: 57.42 - 57.44 Mb
Pubmed search	[1]	[2]

C-src tyrosine kinase, also known as CSK, is a human protein and gene. It includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. This protein specifically phosphorylates Tyr-504 residue on human leukocyte-specific protein tyrosine kinase, which acts as a negative regulatory site. It may also act on the LYN and FYN kinases.

[edit] See also

• Src (gene)
• Tyrosine kinase

[edit] Further reading