BUB1

From Wikipedia, the free encyclopedia

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)

Identifiers

BUB1; BUB1A; BUB1L; hBUB1

External IDs

OMIM: 602452 MGI: 1100510 HomoloGene: 37910

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• kinetochore • nucleus • spindle pole body
Biological Process:	• protein amino acid phosphorylation • cell cycle • mitosis • mitotic cell cycle spindle assembly checkpoint • cell proliferation • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004336 (mRNA)
NP_004327 (protein)

NM_009772 (mRNA)
NP_033902 (protein)

Location

Chr 2: 111.11 - 111.15 Mb

Chr 2: 127.49 - 127.52 Mb

Pubmed search

[1]

[2]

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast), also known as BUB1, is a human gene.

This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.^[1]

[edit] References

^ Entrez Gene: BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Pangilinan F, Li Q, Weaver T, et al. (1998). "Mammalian BUB1 protein kinases: map positions and in vivo expression.". Genomics 46 (3): 379–88. doi:10.1006/geno.1997.5068. PMID 9441741.
Cahill DP, Lengauer C, Yu J, et al. (1998). "Mutations of mitotic checkpoint genes in human cancers.". Nature 392 (6673): 300–3. doi:10.1038/32688. PMID 9521327.
Taylor SS, Ha E, McKeon F (1998). "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.". J. Cell Biol. 142 (1): 1–11. PMID 9660858.
Ouyang B, Lan Z, Meadows J, et al. (1998). "Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.". Cell Growth Differ. 9 (10): 877–85. PMID 9790499.
Jablonski SA, Chan GK, Cooke CA, et al. (1999). "The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis.". Chromosoma 107 (6-7): 386–96. PMID 9914370.
Seeley TW, Wang L, Zhen JY (1999). "Phosphorylation of human MAD1 by the BUB1 kinase in vitro.". Biochem. Biophys. Res. Commun. 257 (2): 589–95. doi:10.1006/bbrc.1999.0514. PMID 10198256.
Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes.". Genomics 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
Jaffrey RG, Pritchard SC, Clark C, et al. (2000). "Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer.". Cancer Res. 60 (16): 4349–52. PMID 10969775.
Steuerwald N, Cohen J, Herrera RJ, et al. (2001). "Association between spindle assembly checkpoint expression and maternal age in human oocytes.". Mol. Hum. Reprod. 7 (1): 49–55. PMID 11134360.
Kaplan KB, Burds AA, Swedlow JR, et al. (2001). "A role for the Adenomatous Polyposis Coli protein in chromosome segregation.". Nat. Cell Biol. 3 (4): 429–32. doi:10.1038/35070123. PMID 11283619.
Wang X, Babu JR, Harden JM, et al. (2001). "The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins.". J. Biol. Chem. 276 (28): 26559–67. doi:10.1074/jbc.M101083200. PMID 11352911.
Shichiri M, Yoshinaga K, Hisatomi H, et al. (2002). "Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.". Cancer Res. 62 (1): 13–7. PMID 11782350.
Taylor SS, Hussein D, Wang Y, et al. (2002). "Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells.". J. Cell. Sci. 114 (Pt 24): 4385–95. PMID 11792804.
Lin SF, Lin PM, Yang MC, et al. (2003). "Expression of hBUB1 in acute myeloid leukemia.". Leuk. Lymphoma 43 (2): 385–91. PMID 11999574.
Ru HY, Chen RL, Lu WC, Chen JH (2002). "hBUB1 defects in leukemia and lymphoma cells.". Oncogene 21 (30): 4673–9. doi:10.1038/sj.onc.1205585. PMID 12096343.
Nakagawa H, Yokozaki H, Oue N, et al. (2003). "No mutations of the Bub1 gene in human gastric and oral cancer cell lines.". Oncol. Rep. 9 (6): 1229–32. PMID 12375025.
Cayrol C, Cougoule C, Wright M (2003). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1.". Biochem. Biophys. Res. Commun. 298 (5): 720–30. PMID 12419313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.