BTN1A1

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Butyrophilin, subfamily 1, member A1
Identifiers
Symbol(s) BTN1A1; BT; BTN
External IDs OMIM: 601610 MGI: 103118 HomoloGene: 1312
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 696 12231
Ensembl ENSG00000124557 ENSMUSG00000000706
Uniprot Q13410 Q3UM26
Refseq NM_001732 (mRNA)
NP_001723 (protein)		 NM_013483 (mRNA)
NP_038511 (protein)
Location Chr 6: 26.61 - 26.62 Mb Chr 13: 23.46 - 23.47 Mb
Pubmed search [1] [2]

Butyrophilin, subfamily 1, member A1, also known as BTN1A1, is a human gene.[1]

Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families[1]

[edit] References

  1. ^ a b Entrez Gene: BTN1A1 butyrophilin, subfamily 1, member A1.

[edit] Further reading

  • Mather IH, Jack LJ (1994). "A review of the molecular and cellular biology of butyrophilin, the major protein of bovine milk fat globule membrane.". J. Dairy Sci. 76 (12): 3832-50. PMID 8132890. 
  • Heid HW, Winter S, Bruder G, et al. (1983). "Butyrophilin, an apical plasma membrane-associated glycoprotein characteristic of lactating mammary glands of diverse species.". Biochim. Biophys. Acta 728 (2): 228-38. PMID 6830779. 
  • Sato T, Takio K, Kobata A, et al. (1995). "Site-specific glycosylation of bovine butyrophilin.". J. Biochem. 117 (1): 147-57. PMID 7775382. 
  • Vernet C, Boretto J, Mattéi MG, et al. (1994). "Evolutionary study of multigenic families mapping close to the human MHC class I region.". J. Mol. Evol. 37 (6): 600-12. PMID 8114113. 
  • Taylor MR, Peterson JA, Ceriani RL, Couto JR (1996). "Cloning and sequence analysis of human butyrophilin reveals a potential receptor function.". Biochim. Biophys. Acta 1306 (1): 1-4. PMID 8611614. 
  • Tazi-Ahnini R, Henry J, Offer C, et al. (1998). "Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex.". Immunogenetics 47 (1): 55-63. PMID 9382921. 
  • Cavaletto M, Giuffrida MG, Giunta C, et al. (1999). "Multiple forms of lactadherin (breast antigen BA46) and butyrophilin are secreted into human milk as major components of milk fat globule membrane.". J. Dairy Res. 66 (2): 295-301. PMID 10376248. 
  • Shibui A, Tsunoda T, Seki N, et al. (1999). "Cloning, expression analysis, and chromosomal localization of a novel butyrophilin-like receptor.". J. Hum. Genet. 44 (4): 249-52. PMID 10429365. 
  • Rhodes DA, Stammers M, Malcherek G, et al. (2001). "The cluster of BTN genes in the extended major histocompatibility complex.". Genomics 71 (3): 351-62. doi:10.1006/geno.2000.6406. PMID 11170752. 
  • McManaman JL, Palmer CA, Wright RM, Neville MC (2003). "Functional regulation of xanthine oxidoreductase expression and localization in the mouse mammary gland: evidence of a role in lipid secretion.". J. Physiol. (Lond.) 545 (Pt 2): 567-79. PMID 12456835. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain.". EMBO J. 25 (6): 1353-63. doi:10.1038/sj.emboj.7600994. PMID 16498413. 
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