BRSK2

From Wikipedia, the free encyclopedia

BR serine/threonine kinase 2

Identifiers

BRSK2; C11orf7; FLJ41362; PEN11B; SAD1; STK29

External IDs

OMIM: 609236 MGI: 1923020 HomoloGene: 55794

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ATP binding • kinase activity • transferase activity
Biological Process:	• protein amino acid phosphorylation • establishment of cell polarity • neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003957 (mRNA)
NP_003948 (protein)

NM_001009929 (mRNA)
NP_001009929 (protein)

Location

Chr 11: 1.37 - 1.44 Mb

Chr 7: 141.76 - 141.81 Mb

Pubmed search

[1]

[2]

BR serine/threonine kinase 2, also known as BRSK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: BRSK2 BR serine/threonine kinase 2.

[edit] Further reading

Miura K, Masuzaki H, Ishimaru T, et al. (1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5.". J. Hum. Genet. 43 (4): 283-4. PMID 9852686.
Miura K, Miyoshi O, Yun K, et al. (1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta.". J. Hum. Genet. 44 (1): 1-9. PMID 9929968.
Stanchi F, Bertocco E, Toppo S, et al. (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences.". Yeast 18 (1): 69-80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833-43. doi:10.1038/sj.emboj.7600110. PMID 14976552.
Lu R, Niida H, Nakanishi M (2004). "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.". J. Biol. Chem. 279 (30): 31164-70. doi:10.1074/jbc.M404728200. PMID 15150265.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Sabater L, Gómez-Choco M, Saiz A, Graus F (2006). "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis.". J. Neuroimmunol. 170 (1-2): 186-90. doi:10.1016/j.jneuroim.2005.08.011. PMID 16165222.
Inoue E, Mochida S, Takagi H, et al. (2006). "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.". Neuron 50 (2): 261-75. doi:10.1016/j.neuron.2006.03.018. PMID 16630837.
Guo Z, Tang W, Yuan J, et al. (2006). "BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.". Biochem. Biophys. Res. Commun. 347 (4): 867-71. doi:10.1016/j.bbrc.2006.06.178. PMID 16870137.