BRD8

From Wikipedia, the free encyclopedia

Bromodomain containing 8

Identifiers

BRD8; p120; SMAP; SMAP2

External IDs

OMIM: 602848 MGI: 1925906 HomoloGene: 41790

Gene ontology
Molecular Function:	• transcription factor activity • ligand-regulated transcription factor activity • transcription coactivator activity • thyroid hormone receptor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of cell growth • transcription • regulation of transcription from RNA polymerase II promoter • cell surface receptor linked signal transduction • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006696 (mRNA)
NP_006687 (protein)

XM_908662 (mRNA)
XP_913755 (protein)

Location

Chr 5: 137.5 - 137.54 Mb

Chr 18: 34.72 - 34.75 Mb

Pubmed search

[1]

[2]

Bromodomain containing 8, also known as BRD8, is a human gene.^[1]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: BRD8 bromodomain containing 8.

[edit] Further reading

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex.". Curr. Opin. Genet. Dev. 14 (2): 147-54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Nielsen MS, Petersen CM, Gliemann J, Madsen P (1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain.". Biochim. Biophys. Acta 1306 (1): 14-6. PMID 8611617.
Monden T, Wondisford FE, Hollenberg AN (1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein.". J. Biol. Chem. 272 (47): 29834-41. PMID 9368056.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Monden T, Kishi M, Hosoya T, et al. (1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.". Mol. Endocrinol. 13 (10): 1695-703. PMID 10517671.
Lai F, Godley LA, Joslin J, et al. (2001). "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q).". Genomics 71 (2): 235-45. doi:10.1006/geno.2000.6414. PMID 11161817.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.". J. Biol. Chem. 278 (44): 42733-6. doi:10.1074/jbc.C300389200. PMID 12963728.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.". Mol. Cell. Biol. 24 (5): 1884-96. PMID 14966270.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.". J. Biol. Chem. 280 (14): 13665-70. doi:10.1074/jbc.M500001200. PMID 15647280.
Benevolenskaya EV, Murray HL, Branton P, et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.". Mol. Cell 18 (6): 623-35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Natsume W, Tanabe K, Kon S, et al. (2006). "SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network.". Mol. Biol. Cell 17 (6): 2592-603. doi:10.1091/mbc.E05-10-0909. PMID 16571680.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.