BRCC3

From Wikipedia, the free encyclopedia

BRCA1/BRCA2-containing complex, subunit 3

Identifiers

BRCC3; BRCC36; C6.1A; CXorf53

External IDs

OMIM: 300617 MGI: 2389572 HomoloGene: 11530

Gene ontology
Molecular Function:	• protein binding • enzyme regulator activity
Cellular Component:	• nuclear ubiquitin ligase complex
Biological Process:	• ubiquitin cycle • response to DNA damage stimulus • response to X-ray

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001018055 (mRNA)
NP_001018065 (protein)

NM_145956 (mRNA)
NP_666068 (protein)

Location

Chr X: 153.95 - 154 Mb

Chr X: 71.67 - 71.71 Mb

Pubmed search

[1]

[2]

BRCA1/BRCA2-containing complex, subunit 3, also known as BRCC3, is a human gene.^[1]

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: BRCC3 BRCA1/BRCA2-containing complex, subunit 3.

[edit] Further reading

Kenwrick S, Levinson B, Taylor S, et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene.". Hum. Mol. Genet. 1 (3): 179–86. PMID 1303175.
Fisch P, Forster A, Sherrington PD, et al. (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another.". Oncogene 8 (12): 3271–6. PMID 8247530.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Dong Y, Hakimi MA, Chen X, et al. (2004). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.". Mol. Cell 12 (5): 1087–99. PMID 14636569.
Ambroggio XI, Rees DC, Deshaies RJ (2006). "JAMM: a metalloprotease-like zinc site in the proteasome and signalosome.". PLoS Biol. 2 (1): E2. doi:10.1371/journal.pbio.0020002. PMID 14737182.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Boudreau HE, Broustas CG, Gokhale PC, et al. (2007). "Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation.". Int. J. Mol. Med. 19 (1): 29–39. PMID 17143545.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.