Bornyl diphosphate synthase

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In enzymology, a bornyl diphosphate synthase (EC 5.5.1.8) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate $\rightleftharpoons$ (+)-bornyl diphosphate

Hence, this enzyme has one substrate, geranyl diphosphate, and one product, (+)-bornyl diphosphate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is (+)-bornyl-diphosphate lyase (decyclizing). Other names in common use include bornyl pyrophosphate synthase, bornyl pyrophosphate synthetase, (+)-bornylpyrophosphate cyclase, and geranyl-diphosphate cyclase (ambiguous). This enzyme participates in monoterpenoid biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1N1B, 1N1Z, 1N20, 1N21, 1N22, 1N23, and 1N24.

[edit] References

IUBMB entry for 5.5.1.8
BRENDA references for 5.5.1.8 (Recommended.)
PubMed references for 5.5.1.8
PubMed Central references for 5.5.1.8
Google Scholar references for 5.5.1.8
Croteau R, Karp F (1979). "Biosynthesis of monoterpenes: preliminary characterization of bornyl pyrophosphate synthetase from sage (Salvia officinalis) and demonstration that Geranyl pyrophosphate is the preferred substrate for cyclization". Arch. Biochem. Biophys. 198: 512–22. doi:10.1016/0003-9861(79)90526-5. PMID 42356.