Talk:Bohr effect
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[edit] Point of Clarification
According to my animal physiology professor, he said multiple times in lecture that while pH and CO2 levels can cause a Bohr effect, a change in temperature does not. Anybody know? Rrten00 23:34, 31 October 2006 (UTC)
Bohr originally recorded the dependence of O2 affinity on the concentration of CO2. It was later learned that the dominant process underlying his observation was the effect CO2 had on the pH of the solution. Therefore, the dominant phenomenon of the Bohr effect is dependence of O2 affinity on pH. The dependence of O2 affinity on temperature is not the Bohr effect, nor are dependencies of O2 affinity phosphate concentration, chloride concentration, hemoglobin concentration or any number of other factors. For an excellent review of the Bohr effect, see:
The Nature and Significance of the Bohr Effect in Mammalian Hemoglobins Austen Riggs The Journal of General Physiology(43)737-52.
Since that review, work has been completed that identified amino acid side chains in at least human and lamprey hemoglobins that contribute to the Bohr effect in these proteins. There are many studies including this one
Biochemistry, 36 (22), 6663-73.
