BNIP3L

From Wikipedia, the free encyclopedia

BCL2/adenovirus E1B 19kDa interacting protein 3-like

Identifiers

BNIP3L; BNIP3a; NIX

External IDs

OMIM: 605368 MGI: 1332659 HomoloGene: 3195

Gene ontology
Molecular Function:	• lamin binding • protein homodimerization activity • protein heterodimerization activity
Cellular Component:	• nucleus • nuclear envelope • mitochondrion • mitochondrial envelope • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• apoptosis • induction of apoptosis • negative regulation of survival gene product activity • positive regulation of apoptosis • negative regulation of apoptosis • defense response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004331 (mRNA)
NP_004322 (protein)

NM_009761 (mRNA)
NP_033891 (protein)

Location

Chr 8: 26.3 - 26.33 Mb

Chr 14: 65.94 - 65.96 Mb

Pubmed search

[1]

[2]

BCL2/adenovirus E1B 19kDa interacting protein 3-like, also known as BNIP3L, is a human gene.^[1]

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.^[1]

[edit] References

^ ^a ^b Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like.

[edit] Further reading

Matsushima M, Fujiwara T, Takahashi E, et al. (1998). "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.". Genes Chromosomes Cancer 21 (3): 230–5. PMID 9523198.
Chen G, Cizeau J, Vande Velde C, et al. (1999). "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.". J. Biol. Chem. 274 (1): 7–10. PMID 9867803.
Yasuda M, Han JW, Dionne CA, et al. (1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3.". Cancer Res. 59 (3): 533–7. PMID 9973195.
Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
Imazu T, Shimizu S, Tagami S, et al. (1999). "Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability.". Oncogene 18 (32): 4523–9. doi:10.1038/sj.onc.1202722. PMID 10467396.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Passer BJ, Nancy-Portebois V, Amzallag N, et al. (2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMID 12606722.
Aerbajinai W, Giattina M, Lee YT, et al. (2003). "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.". Blood 102 (2): 712–7. doi:10.1182/blood-2002-11-3324. PMID 12663450.
Sun JL, He XS, Yu YH, Chen ZC (2004). "[Expression and structure of BNIP3L in lung cancer]". Ai Zheng 23 (1): 8–14. PMID 14720367.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Fei P, Wang W, Kim SH, et al. (2005). "Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.". Cancer Cell 6 (6): 597–609. doi:10.1016/j.ccr.2004.10.012. PMID 15607964.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Stepan H, Leo C, Purz S, et al. (2006). "Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome.". Eur. J. Obstet. Gynecol. Reprod. Biol. 122 (2): 172–6. doi:10.1016/j.ejogrb.2005.01.017. PMID 16219518.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.