BMP8B

From Wikipedia, the free encyclopedia

Bone morphogenetic protein 8b (osteogenic protein 2)

Identifiers

BMP8B; BMP8; MGC131757; OP2

External IDs

Gene ontology
Molecular Function:	• cytokine activity • growth factor activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• ossification • multicellular organismal development • cell differentiation • growth • cartilage development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001720 (mRNA)
NP_001711 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 40 - 40.03 Mb

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Pubmed search

[1]

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Bone morphogenetic protein 8b (osteogenic protein 2), also known as BMP8B, is a human gene.^[1]

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.^[1]

[edit] References

^ ^a ^b Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2).

[edit] Further reading

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Wen XZ, Akiyama Y, Baylin SB, Yuasa Y (2006). "Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas.". Oncogene 25 (18): 2666-73. doi:10.1038/sj.onc.1209297. PMID 16314833.
Saito T, Ji G, Shinzawa H, et al. (2004). "Genetic variations in humans associated with differences in the course of hepatitis C.". Biochem. Biophys. Res. Commun. 317 (2): 335-41. doi:10.1016/j.bbrc.2004.03.056. PMID 15063762.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ying Y, Qi X, Zhao GQ (2001). "Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways.". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7858-62. doi:10.1073/pnas.151242798. PMID 11427739.
Ying Y, Liu XM, Marble A, et al. (2000). "Requirement of Bmp8b for the generation of primordial germ cells in the mouse.". Mol. Endocrinol. 14 (7): 1053-63. PMID 10894154.
DiLeone RJ, King JA, Storm EE, et al. (1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.". Genomics 40 (1): 196-8. doi:10.1006/geno.1996.4533. PMID 9070944.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263-72. PMID 7757816.
Ozkaynak E, Schnegelsberg PN, Jin DF, et al. (1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.". J. Biol. Chem. 267 (35): 25220-7. PMID 1460021.