BLCAP

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Bladder cancer associated protein
Identifiers
Symbol(s) BLCAP; BC10
External IDs MGI: 1858907 HomoloGene: 38217
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10904 53619
Ensembl ENSG00000166619 ENSMUSG00000067787
Uniprot P62952 Q3TD76
Refseq NM_006698 (mRNA)
NP_006689 (protein)		 NM_016916 (mRNA)
NP_058612 (protein)
Location Chr 20: 35.58 - 35.59 Mb Chr 2: 157.25 - 157.26 Mb
Pubmed search [1] [2]

Bladder cancer associated protein, also known as BLCAP, is a human gene.[1]

The protein encoded by this gene was identified using a differential display procedure with tumor biopsies obtained from a noninvasive and an invasive bladder transitional cell carcinoma. Although database searches revealed no homology to any human gene at the time of identification, mouse, rat and zebrafish orthologs have since been identified. The function of this differentially expressed protein is not yet known but it appears to be down-regulated during bladder cancer progression.[1]

[edit] References

  1. ^ a b Entrez Gene: BLCAP bladder cancer associated protein.

[edit] Further reading

  • Yao J, Duan L, Fan M, et al. (2007). "Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma : BLCAP overexpression induces S phase arrest and apoptosis.". Mol. Cell. Biochem. 297 (1-2): 81-92. doi:10.1007/s11010-006-9332-2. PMID 17031575. 
  • Zuo Z, Zhao M, Liu J, et al. (2006). "Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma.". Tumour Biol. 27 (4): 221-6. doi:10.1159/000093057. PMID 16675915. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Gromova I, Gromov P, Celis JE (1999). "Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure.". Electrophoresis 20 (2): 241-8. doi:10.1002/(SICI)1522-2683(19990201)20:2<241::AID-ELPS241>3.0.CO;2-A. PMID 10197429. 
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