Biphenyl-2,3-diol 1,2-dioxygenase

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In enzymology, a biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) is an enzyme that catalyzes the chemical reaction

biphenyl-2,3-diol + O₂ $\rightleftharpoons$ 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H₂O

Thus, the two substrates of this enzyme are biphenyl-2,3-diol and O₂, whereas its two products are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 2,3-dihydroxybiphenyl dioxygenase, and biphenyl-2,3-diol dioxygenase. This enzyme participates in gamma-hexachlorocyclohexane degradation and biphenyl degradation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 1DHY, 1EIL, 1EIQ, 1EIR, 1HAN, 1KMY, 1KND, 1KNF, 1KW3, 1KW6, 1KW8, 1KW9, 1KWB, 1KWC, 1LGT, and 1LKD.