Talk:Bioavailability

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[edit] Ecological Bioavailability

Can we have a discussion about bioavailability in the context of ecology? For instance, what it means for a particular molecule to be bioavailable to a microbe. I think this is an important definition of bioavailability, though, I'm not the one to define it. Any takers?

--Jen Duane 08:28, 15 November 2005 (UTC)

[edit] Explanation please...

In the formula for Absolute Availability: F = \frac{[AUC]_{po}*dose_{IV}}{[AUC]_{IV}*dose_{po}}, what does the 'po' mean? I guess it is related to 'extra-vascular', but it is not obvious.

What does the 'dose-corrected AUC' mean?

Hi Duncan.france, "po" is conventional medical abbreviation for per os (by mouth). It made more sense when I originally wrote this article, because (to keep things simple) I only referred to absolute bioavailability of orally-administered drugs. But since people have added comments about other extravascular routes, I've now modified the text to try to explain. Dose corrected AUC means that doses of the drug given IV or non-IV can be different, so the formula for calculating F takes this into account. Hope that helps – let me know if it needs to be clarified further in the text. -Techelf 09:14, 20 March 2006 (UTC)

the formula is wrong... see http://www.chm.davidson.edu/erstevens/AUC/AUC.html

The page you cite actually just contains another way of expressing the same formula (think about it)... -Techelf 10:56, 4 April 2006 (UTC)

Are you sure that bioavailibility means "amount observed in blood relative to amount administered"? I've seen several definitions and some of them are more of the form "amount delivered to target tissue relative to amount administered". With the first definition, if you delivered a CNS drug intrathecally, you would have a bioavaibility actually less than the effectice dose to the target tissue which seems somewhat strange to me. 69.37.255.177 16:32, 17 June 2007 (UTC)GMM

Now Doctors Professors,students Please i've been trying to find the factors influencing bioavailability in clinical situations for around a week & i didn't get nothing till now & i'm having a serious problem with this assignment thanks... —Preceding unsigned comment added by 202.125.143.65 (talk) 17:03, 6 November 2007 (UTC)