BICD2

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Bicaudal D homolog 2 (Drosophila)
Identifiers
Symbol(s) BICD2; KIAA0699; bA526D8.1
External IDs OMIM: 609797 MGI: 1924145 HomoloGene: 9070
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23299 76895
Ensembl ENSG00000185963 ENSMUSG00000037933
Uniprot Q8TD16 Q3TBD4
Refseq NM_001003800 (mRNA)
NP_001003800 (protein)		 NM_001039179 (mRNA)
NP_001034268 (protein)
Location Chr 9: 94.51 - 94.57 Mb Chr 13: 49.35 - 49.4 Mb
Pubmed search [1] [2]

Bicaudal D homolog 2 (Drosophila), also known as BICD2, is a human gene.[1]

This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: BICD2 bicaudal D homolog 2 (Drosophila).

[edit] Further reading

  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811. 
  • Hoogenraad CC, Akhmanova A, Howell SA, et al. (2001). "Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.". EMBO J. 20 (15): 4041–54. doi:10.1093/emboj/20.15.4041. PMID 11483508. 
  • Holland PM, Milne A, Garka K, et al. (2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.". J. Biol. Chem. 277 (18): 16229–40. doi:10.1074/jbc.M108662200. PMID 11864968. 
  • Short B, Preisinger C, Schaletzky J, et al. (2003). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.". Curr. Biol. 12 (20): 1792–5. PMID 12401177. 
  • Matanis T, Akhmanova A, Wulf P, et al. (2003). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.". Nat. Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hoogenraad CC, Wulf P, Schiefermeier N, et al. (2004). "Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport.". EMBO J. 22 (22): 6004–15. doi:10.1093/emboj/cdg592. PMID 14609947. 
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
  • Fuchs E, Short B, Barr FA (2006). "Assay and properties of rab6 interaction with dynein-dynactin complexes.". Meth. Enzymol. 403: 607–18. doi:10.1016/S0076-6879(05)03053-3. PMID 16473624. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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