Betaine-homocysteine S-methyltransferase
From Wikipedia, the free encyclopedia
In enzymology, a betaine-homocysteine S-methyltransferase (EC 2.1.1.5) is an enzyme that catalyzes the chemical reaction
- trimethylammonioacetate + L-homocysteine
dimethylglycine + L-methionine
Thus, the two substrates of this enzyme are trimethylammonioacetate and L-homocysteine, whereas its two products are dimethylglycine and L-methionine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is trimethylammonioacetate:L-homocysteine S-methyltransferase. Other names in common use include betaine-homocysteine methyltransferase, and betaine-homocysteine transmethylase. This enzyme participates in the metabolism of glycine, serine, threonine and also methionine.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1LT7, 1LT8, and 1UMY.
[edit] References
- IUBMB entry for 2.1.1.5
- BRENDA references for 2.1.1.5 (Recommended.)
- PubMed references for 2.1.1.5
- PubMed Central references for 2.1.1.5
- Google Scholar references for 2.1.1.5
- KLEE WA, RICHARDS HH, CANTONI GL (1961). "The synthesis of methionine by enzymic transmethylation. VII Existence of two separate homocysteine methylpherases on mammalian liver". Biochim. Biophys. Acta. 54: 157–64. doi:. PMID 14456704.
[edit] External links
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- The CAS registry number for this enzyme class is 9029-78-1.
[edit] Gene Ontology (GO) codes
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