Beta-ketoacyl-(acyl-carrier-protein) synthase III

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In enzymology, a beta-ketoacyl-[acyl-carrier-protein] synthase III (EC 2.3.1.180) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + malonyl-[acyl-carrier-protein] $\rightleftharpoons$ acetoacetyl-[acyl-carrier-protein] + CoA + CO₂

Thus, the two substrates of this enzyme are acetyl-CoA and [[malonyl-[acyl-carrier-protein]]], whereas its 3 products are [[acetoacetyl-[acyl-carrier-protein]]], CoA, and CO₂.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase. Other names in common use include 3-oxoacyl:ACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, KASIII, KAS III, FabH, beta-ketoacyl-acyl carrier protein synthase III, beta-ketoacyl-ACP synthase III, beta-ketoacyl (acyl carrier protein) synthase III, and beta-ketoacyl-acyl-carrier-protein synthase III. This enzyme participates in fatty acid biosynthesis.

[edit] References

IUBMB entry for 2.3.1.180
BRENDA references for 2.3.1.180 (Recommended.)
PubMed references for 2.3.1.180
PubMed Central references for 2.3.1.180
Google Scholar references for 2.3.1.180
Tsay JT, Oh W, Larson TJ, Jackowski S, Rock CO (1992). "Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12". J. Biol. Chem. 267: 6807–14. PMID 1551888.
Han L, Lobo S, Reynolds KA (1998). "Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis". J. Bacteriol. 180: 4481–6. PMID 9721286.
Lonsdale JT (2001). "Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)". J. Biol. Chem. 276: 30024–30. doi:10.1074/jbc.M101769200. PMID 11375394.
Choi KH, Kremer L, Besra GS, Rock CO (2000). "Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis". J. Biol. Chem. 275: 28201–7. PMID 10840036.
Khandekar SS (2005). "Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus". Protein. Sci. 14: 2087–94. doi:10.1110/ps.051501605. PMID 15987898.
Li Y, Florova G, Reynolds KA (2005). "Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH)". J. Bacteriol. 187: 3795–9. doi:10.1128/JB.187.11.3795-3799.2005. PMID 15901703.
Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.