Beta-actin

From Wikipedia, the free encyclopedia

Actin, beta

PDB rendering based on 1atn.

Available structures: 1atn, 1c0f, 1c0g, 1d4x, 1dej, 1eqy, 1esv, 1h1v, 1hlu, 1ijj, 1j6z, 1kxp, 1lcu, 1lot, 1m8q, 1ma9, 1mdu, 1mvw, 1nlv, 1nm1, 1nmd, 1nwk, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g, 1p8z, 1qz5, 1qz6, 1rdw, 1rfq, 1rgi, 1s22, 1sqk, 1t44, 1wua, 1y64, 1yxq, 2a3z, 2a40, 2a41, 2a42, 2a5x, 2asm, 2aso, 2asp, 2btf, 2d1k, 2ff3, 2ff6, 2fxu, 2gwj, 2gwk, 2hf3, 2hf4, 2hmp, 2oan, 2q1n, 2q31, 2q36

Identifiers

Symbol(s)

ACTB; PS1TP5BP1

External IDs

OMIM: 102630 MGI: 87904 HomoloGene: 74383

Gene ontology
Molecular Function:	• nucleotide binding • structural constituent of cytoskeleton • protein binding • ATP binding
Cellular Component:	• soluble fraction • cytoplasm • cytosol • cytoskeleton • NuA4 histone acetyltransferase complex
Biological Process:	• cell motility • sensory perception of sound

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001101 (mRNA)
NP_001092 (protein)

NM_007393 (mRNA)
NP_031419 (protein)

Location

Chr 7: 5.53 - 5.54 Mb

Chr 5: 143.17 - 143.17 Mb

Pubmed search

[1]

[2]

Beta-actin (gene name ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.^[1]

[edit] References

^ Entrez Gene: ACTB actin, beta.

[edit] Further reading

Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227–30. PMID 8997639.
Gunning P, Weinberger R, Jeffrey P (1997). "Actin and tropomyosin isoforms in morphogenesis.". Anat. Embryol. 195 (4): 311–5. PMID 9108196.
Kimura T, Hashimoto I, Nishikawa M, Fujisawa JI (1997). "A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression.". Biochimie 78 (11-12): 1075–80. PMID 9150887.
Szentirmay MN, Sawadogo M (2000). "Spatial organization of RNA polymerase II transcription in the nucleus.". Nucleic Acids Res. 28 (10): 2019–25. PMID 10773068.
Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell.". Current HIV/AIDS reports 1 (1): 47–53. PMID 16091223.
Pederson T, Aebi U (2006). "Nuclear actin extends, with no contraction in sight.". Mol. Biol. Cell 16 (11): 5055–60. doi:10.1091/mbc.E05-07-0656. PMID 16148048.