Talk:Benzopyrene

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?? —The preceding unsigned comment was added by 60.48.25.2 (talk • contribs) 18 November 2005.

I dont know what did you mean by ??.Can you specify your question?HappyApple 19:26, 18 November 2005 (UTC)

Note to contributors/self: add BaP biochemistry references. Lots of scientific reviews have been written, the introductions are usually quite useful for coherent background information. Jed 16:52, 3 January 2006 (UTC)

[edit] Tidy

I think that the interaction paragraph needs tidying. It is not accessible to most people and is hard to read even for experts. What is needed is a more qualitative account, where it is said what is epoxidized. Listing all the chemical names is counterproductive. They can be provided for reference, but should not be in the bulk of the text. I am going to edit it heavily very soon unless original or other interested authors do it. --Vuo 09:53, 15 December 2006 (UTC)

Did some work on the interaction paragraph and the introduction. Should be clearer. I'll leave the clarification note up until someone else comments on this, preferably someone not as intimate with the gory details of the mechanisms as I am. Jed 17:32, 29 December 2006 (UTC)

Well, it's still Greek to me, a poor layperson. Annodeus 18:30, 24 January 2007 (UTC)

—Preceding unsigned comment added by 66.24.24.5 (talk) 19:55, 24 November 2007 (UTC)

What's the most confusing part? It's actually quite important for BaP toxicity that it's not the BaP itself that's toxic, but the metabolite. Given that this is one of the few environmental chemicals that we actually know a lot about the actual molecular specifics of carcinogenisis for, I think it's worth including some of the information. Could be summarized and the detail put into a separate paragraph. Jed 23:33, 2 February 2007 (UTC)

[edit] Ultimate Carcinogen?

This article calls benzo[a]pyrene diol the ultimate carcinogen - is that a fair classification? 66.24.24.5 (talk) 19:59, 24 November 2007 (UTC)

The wording may not be clear — the point is that benzopyrene is not carcinogenic, only its metabolic product is. Similarly you would say that methanol is not the poison in a methanol poisoning, its metabolic product formic acid is the ultimate poison. The "ultimate" carcinogen in absolute terms (compared to all other substances) is usually taken to be TCDD, or 2,4,7,8-tetrachlorodibenzo-p-dioxin. --Vuo (talk) 21:50, 24 November 2007 (UTC)