Benzylthiouracil
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Benzylthiouracil
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| Systematic (IUPAC) name | |
| 1-(1-cyclohexa-2,4-dienylmethyl)-7-thia- 3,5-diazabicyclo[4.1.0]hepta-3,5-dien-2-one |
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| Identifiers | |
| CAS number | |
| ATC code | H03 |
| PubChem | |
| Chemical data | |
| Formula | C11H10N2OS |
| Mol. mass | 218.276 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.
[edit] Adverse effects
Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.[1][2][3][4]
[edit] References
- ^ Tieulie N, Huong DL, Andreu M, et al (2002). "[ANCA associated glomerulonephritis related to benzylthiouracil]" (in French). Rev Med Interne 23 (10): 853–6. PMID 12428489.
- ^ Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H (2002). "[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease]" (in French). Rev Med Interne 23 (10): 857–61. PMID 12428490.
- ^ Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M (2004). "[Benzylthiouracil induced ANCA-positive vasculitis]" (in French). Presse médicale 33 (19 Pt 1): 1331–3. PMID 15615240.
- ^ Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS (2006). "ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil". Eur J Pediatr 165 (7): 435–6. doi:. PMID 16622664.
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