Benzylsuccinate synthase

From Wikipedia, the free encyclopedia

In enzymology, a benzylsuccinate synthase (EC 4.1.99.11) is an enzyme that catalyzes the chemical reaction

benzylsuccinate toluene + fumarate

Hence, this enzyme has one substrate, benzylsuccinate, and two products, toluene and fumarate.

This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is benzylsuccinate fumarate-lyase (toluene-forming). This enzyme is also called benzylsuccinate fumarate-lyase. This enzyme participates in benzoate degradation via coa ligation.

[edit] References

• IUBMB entry for 4.1.99.11
• BRENDA references for 4.1.99.11 (Recommended.)
• PubMed references for 4.1.99.11
• PubMed Central references for 4.1.99.11
• Google Scholar references for 4.1.99.11
• Beller HR, Spormann AM (1998). "Analysis of the novel benzylsuccinate synthase reaction for anaerobic toluene activation based on structural studies of the product". J. Bacteriol. 180: 5454–7. PMID 9765580. 
• Schagger H, Heider J (1998). "Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism". Mol. Microbiol. 28: 615–28. doi:10.1046/j.1365-2958.1998.00826.x. PMID 9632263. 

[edit] External links

• IUBMB entry for 4.1.99.11

• KEGG entry for 4.1.99.11

• BRENDA entry for 4.1.99.11

• NiceZyme view of 4.1.99.11

• EC2PDB: PDB structures for 4.1.99.11

• PRIAM entry for 4.1.99.11

• PUMA2 entry for 4.1.99.11

• IntEnz: Integrated Enzyme entry for 4.1.99.11

• MetaCyc entry for 4.1.99.11

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018805: benzylsuccinate synthase

• AMIGO entry for GO code 0018805: benzylsuccinate synthase