BECN1

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Beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
PDB rendering based on 2p1l.
Available structures: 2p1l
Identifiers
Symbol(s) BECN1; ATG6; VPS30
External IDs OMIM: 604378 MGI: 1891828 HomoloGene: 2794
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8678 56208
Ensembl ENSG00000126581 ENSMUSG00000035086
Uniprot Q14457 Q99J03
Refseq NM_003766 (mRNA)
NP_003757 (protein)		 XM_001005066 (mRNA)
XP_001005066 (protein)
Location Chr 17: 38.22 - 38.23 Mb Chr 11: 101.1 - 101.12 Mb
Pubmed search [1] [2]

Beclin 1 (coiled-coil, myosin-like BCL2 interacting protein), also known as BECN1, is a human gene.[1]

Beclin-1 is also known as autophagy-related gene (Atg) 6. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagasome in autophagy.

[edit] References

  1. ^ Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein).

[edit] Further reading

  • Rommens JM, Durocher F, McArthur J, et al. (1996). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.". Genomics 28 (3): 530–42. PMID 7490091. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Liang XH, Kleeman LK, Jiang HH, et al. (1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.". J. Virol. 72 (11): 8586–96. PMID 9765397. 
  • Aita VM, Liang XH, Murty VV, et al. (1999). "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.". Genomics 59 (1): 59–65. doi:10.1006/geno.1999.5851. PMID 10395800. 
  • Liang XH, Jackson S, Seaman M, et al. (2000). "Induction of autophagy and inhibition of tumorigenesis by beclin 1.". Nature 402 (6762): 672–6. doi:10.1038/45257. PMID 10604474. 
  • Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T (2001). "Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network.". EMBO Rep. 2 (4): 330–5. doi:10.1093/embo-reports/kve061. PMID 11306555. 
  • Liang XH, Yu J, Brown K, Levine B (2001). "Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function.". Cancer Res. 61 (8): 3443–9. PMID 11309306. 
  • Weinmann AS, Bartley SM, Zhang T, et al. (2001). "Use of chromatin immunoprecipitation to clone novel E2F target promoters.". Mol. Cell. Biol. 21 (20): 6820–32. doi:10.1128/MCB.21.20.6820-6832.2001. PMID 11564866. 
  • Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice.". Neuron 35 (5): 921–33. PMID 12372286. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Song H, Xia SL, Liao C, et al. (2004). "Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma.". World J. Gastroenterol. 10 (4): 509–13. PMID 14966907. 
  • Scarlatti F, Bauvy C, Ventruti A, et al. (2004). "Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.". J. Biol. Chem. 279 (18): 18384–91. doi:10.1074/jbc.M313561200. PMID 14970205. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Furuya D, Tsuji N, Yagihashi A, Watanabe N (2005). "Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity.". Exp. Cell Res. 307 (1): 26–40. doi:10.1016/j.yexcr.2005.02.023. PMID 15922724. 
  • Kruse KB, Brodsky JL, McCracken AA (2006). "Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.". Mol. Biol. Cell 17 (1): 203–12. doi:10.1091/mbc.E04-09-0779. PMID 16267277. 
  • Zeng X, Overmeyer JH, Maltese WA (2006). "Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking.". J. Cell. Sci. 119 (Pt 2): 259–70. doi:10.1242/jcs.02735. PMID 16390869. 
  • Shibata M, Lu T, Furuya T, et al. (2006). "Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.". J. Biol. Chem. 281 (20): 14474–85. doi:10.1074/jbc.M600364200. PMID 16522639. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Daniel F, Legrand A, Pessayre D, et al. (2006). "Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells.". World J. Gastroenterol. 12 (18): 2895–900. PMID 16718815. 
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