BCLAF1

From Wikipedia, the free encyclopedia

BCL2-associated transcription factor 1

Identifiers

BCLAF1; BTF; KIAA0164; bK211L9.1

External IDs

MGI: 1917580 HomoloGene: 8832

Gene ontology
Molecular Function:	• DNA binding • protein binding • transcription repressor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • induction of apoptosis • negative regulation of transcription

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001077440 (mRNA)
NP_001070908 (protein)

XM_001052039 (mRNA)
XP_001052039 (protein)

Location

n/a

Chr 10: 20 - 20.03 Mb

Pubmed search

[1]

[2]

BCL2-associated transcription factor 1, also known as BCLAF1, is a human gene.^[1]

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: BCLAF1 BCL2-associated transcription factor 1.

[edit] Further reading

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849.
Kasof GM, Goyal L, White E (1999). "Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins.". Mol. Cell. Biol. 19 (6): 4390–404. PMID 10330179.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Haraguchi T, Holaska JM, Yamane M, et al. (2004). "Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy.". Eur. J. Biochem. 271 (5): 1035–45. PMID 15009215.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zheng H, Hu P, Quinn DF, Wang YK (2005). "Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography.". Mol. Cell Proteomics 4 (6): 721–30. doi:10.1074/mcp.M400077-MCP200. PMID 15659558.
Mansharamani M, Wilson KL (2005). "Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor.". J. Biol. Chem. 280 (14): 13863–70. doi:10.1074/jbc.M413020200. PMID 15681850.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Liu H, Lu ZG, Miki Y, Yoshida K (2007). "Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.". Mol. Cell. Biol. 27 (24): 8480–91. doi:10.1128/MCB.01126-07. PMID 17938203.