BCL2L12

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BCL2-like 12 (proline rich)
Identifiers
Symbol(s) BCL2L12; MGC120313; MGC120314; MGC120315
External IDs MGI: 1922986 HomoloGene: 12619
Orthologs
Human Mouse
Entrez 83596 75736
Ensembl ENSG00000126453 ENSMUSG00000003190
Uniprot Q9HB09 n/a
Refseq NM_001040668 (mRNA)
NP_001035758 (protein)		 NM_029410 (mRNA)
NP_083686 (protein)
Location Chr 19: 54.86 - 54.87 Mb Chr 7: 44.86 - 44.87 Mb
Pubmed search [1] [2]

BCL2-like 12 (proline rich), also known as BCL2L12, is a human gene.[1]

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: BCL2L12 BCL2-like 12 (proline rich).

[edit] Further reading

  • Hammond PW, Alpin J, Rise CE, et al. (2001). "In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries.". J. Biol. Chem. 276 (24): 20898–906. doi:10.1074/jbc.M011641200. PMID 11283018. 
  • Scorilas A, Kyriakopoulou L, Yousef GM, et al. (2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family.". Genomics 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Talieri M, Diamandis EP, Katsaros N, et al. (2004). "Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors.". Thromb. Haemost. 89 (6): 1081–8. doi:10.1267/THRO03061081. PMID 12783122. 
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Mathioudaki K, Scorilas A, Papadokostopoulou A, et al. (2005). "Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer.". Biol. Chem. 385 (9): 779–83. PMID 15493871. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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