BCAS1

From Wikipedia, the free encyclopedia


Breast carcinoma amplified sequence 1
Identifiers
Symbol(s) BCAS1; AIBC1; NABC1
External IDs OMIM: 602968 MGI: 1924210 HomoloGene: 2714
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8537 76960
Ensembl ENSG00000064787 ENSMUSG00000013523
Uniprot O75363 Q80ZP3
Refseq NM_003657 (mRNA)
NP_003648 (protein)		 NM_029815 (mRNA)
NP_084091 (protein)
Location Chr 20: 51.99 - 52.12 Mb Chr 2: 170.04 - 170.12 Mb
Pubmed search [1] [2]

Breast carcinoma amplified sequence 1, also known as BCAS1, is a human gene.[1]

Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.[1]

[edit] References

  1. ^ a b Entrez Gene: BCAS1 breast carcinoma amplified sequence 1.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Tanner MM, Tirkkonen M, Kallioniemi A, et al. (1996). "Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer.". Cancer Res. 56 (15): 3441–5. PMID 8758909. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Collins C, Rommens JM, Kowbel D, et al. (1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8703–8. PMID 9671742. 
  • Correa RG, de Carvalho AF, Pinheiro NA, et al. (2000). "NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors.". Genomics 65 (3): 299–302. doi:10.1006/geno.2000.6172. PMID 10857754. 
  • Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Beardsley DI, Kowbel D, Lataxes TA, et al. (2003). "Characterization of the novel amplified in breast cancer-1 (NABC1) gene product.". Exp. Cell Res. 290 (2): 402–13. PMID 14567997. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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