Basal-like carcinoma
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The basal-like carcinoma is a newly proposed subtype of breast cancer defined by its gene expression and protein expression profile[1]. In the current WHO breast tumor classification, these tumors are classified as ductal carcinoma. They are high grade, "triple-negative" tumors, i.e. they express no estrogen receptor, progesterone receptor nor Her2/neu proteins.
Basal-like carcinomas tend to be more aggressive, with a poor prognosis. In the U.S., they are more frequent among black women, which may explain the higher mortality rate in this group.
[edit] References
- ^ Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma, Modern Pathology 19:264-271 (2006), via www.nature.com
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