From Wikipedia, the free encyclopedia
Bapineuzumab is a humanized monoclonal antibody which acts on the nervous system and has potential therapeutic value for the treatment of Alzheimer's disease and quite possibly Glaucoma [1]. Bapineuzumab is an antibody to the beta-amyloid (Aβ) plaques that are believed to underlie Alzheimer's disease neuropathology. Previous clinical trials for the first iteration of the drug, called AN-1792, patients with Alzheimer's disease using active immunization had positive outcomes with removal of plaques and quality of life increases, but 6% of subjects developed aseptic meningitis and the trial was stopped last decade(for a review, see Woodhouse et al. 2007 [2]). Bapineuzumab is currently being co-developed by the pharmaceutical companies Élan and Wyeth and has just entered Phase III trials.
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Humanized monoclonal antibodies ("-zu-") |
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| "-tuzu-" (tumor) |
Alemtuzumab, Bevacizumab/ Ranibizumab, Bivatuzumab mertansine, Cantuzumab mertansine, Dacetuzumab, Etaracizumab, Etaratuzumab, Gemtuzumab ozogamicin, Inotuzumab ozogamicin, Labetuzumab, Lintuzumab, Matuzumab, Nimotuzumab, Pertuzumab, Sibrotuzumab, Sontuzumab, Tacatuzumab tetraxetan, Trastuzumab, Tucotuzumab celmoleukin
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| "-lizu-" (immune system) |
Aselizumab, Atlizumab, Apolizumab, Cedelizumab, Certolizumab pegol, Daclizumab, Eculizumab, Efalizumab, Epratuzumab, Erlizumab, Fontolizumab, Ibalizumab, Lebrilizumab, Mepolizumab, Natalizumab, Ocrelizumab, Omalizumab, Pascolizumab, Pexelizumab, Reslizumab, Rovelizumab, Ruplizumab, Siplizumab, Talizumab, Teplizumab, Tocilizumab, Toralizumab, Visilizumab
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| "-bazu-" (bacterial) |
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| "-cizu-" (cardiovascular) |
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| "-neuzu-" (nervous system) |
Bapineuzumab
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| "-toxazu-" (toxin as target) |
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| "-vizu-" (viral infections) |
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