Bag-1 internal ribosome entry site (IRES)

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Bag-1 internal ribosome entry site (IRES)
Type: Cis-reg; IRES; 2° structure: Predicted; PFOLD Seed alignment: http://ifr31w3.toulouse.inserm.fr/IRESdatabase/ Avg length: 349.8 nucleotides Avg identity: 86%

The bag-1 internal ribosome entry site (IRES) is a cis-acting element located in the 5 ' untranslated region of the BAG-1 protein mRNA. Its effects apoptosis through IRES mediated translation of the BAG-1 protein.

When expressed, the BAG-1 protein is known to enhance the anti-apoptotic properties of the Bcl-2 protein. Although bag-1 translation usually occurs via a cap-dependent mechanism it has been found to contain an IRES in its 5' UTR. Translation via the IRES has been found to be common following heat shock when cap-dependent scanning is compromised ^[1].

[edit] References

1. ^ Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE (2001). "The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock". Oncogene 20 (30): 4095–100. doi:10.1038/sj.onc.1204547. PMID 11494137. 

[edit] External links

• Rfam page for Bag-1 internal ribosome entry site (IRES)