Baculoviral IAP repeat-containing protein 3

From Wikipedia, the free encyclopedia

Baculoviral IAP repeat-containing 3

PDB rendering based on 2uvl.

Available structures: 2uvl

Identifiers

Symbol(s)

BIRC3; AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49

External IDs

OMIM: 601721 MGI: 1197007 HomoloGene: 899

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus • cytoplasm
Biological Process:	• anti-apoptosis • cell surface receptor linked signal transduction • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001165 (mRNA)
NP_001156 (protein)

NM_007464 (mRNA)
NP_031490 (protein)

Location

Chr 11: 101.69 - 101.71 Mb

n/a

Pubmed search

[1]

[2]

Baculoviral IAP repeat-containing 3, also known as BIRC3, is a human gene.

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.^[1]

[edit] References

^ Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3.

[edit] Further reading

Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma.". Hematol. J. 3 (1): 10-3. doi:10.1038/sj/thj/6200146. PMID 11960389.
Rothe M, Pan MG, Henzel WJ, et al. (1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.". Cell 83 (7): 1243-52. PMID 8548810.
Liston P, Roy N, Tamai K, et al. (1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.". Nature 379 (6563): 349-53. doi:10.1038/379349a0. PMID 8552191.
Uren AG, Pakusch M, Hawkins CJ, et al. (1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974-8. PMID 8643514.
Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). "Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization.". Genomics 37 (3): 404-6. doi:10.1006/geno.1996.0579. PMID 8938457.
Roy N, Deveraux QL, Takahashi R, et al. (1998). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.". EMBO J. 16 (23): 6914-25. doi:10.1093/emboj/16.23.6914. PMID 9384571.
Deveraux QL, Roy N, Stennicke HR, et al. (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.". EMBO J. 17 (8): 2215-23. doi:10.1093/emboj/17.8.2215. PMID 9545235.
Young SS, Liston P, Xuan JY, et al. (1999). "Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.". Mamm. Genome 10 (1): 44-8. PMID 9892732.
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, et al. (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.". Blood 93 (10): 3418-31. PMID 10233894.
Suzuki H, Motegi M, Akagi T, et al. (1999). "API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21)". Blood 94 (9): 3270-1. PMID 10610122.
Huang H, Joazeiro CA, Bonfoco E, et al. (2000). "The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.". J. Biol. Chem. 275 (35): 26661-4. doi:10.1074/jbc.C000199200. PMID 10862606.
Verhagen AM, Ekert PG, Pakusch M, et al. (2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.". Cell 102 (1): 43-53. PMID 10929712.
Baens M, Steyls A, Dierlamm J, et al. (2001). "Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.". Genes Chromosomes Cancer 29 (4): 281-91. PMID 11066071.
Werneburg BG, Zoog SJ, Dang TT, et al. (2001). "Molecular characterization of CD40 signaling intermediates.". J. Biol. Chem. 276 (46): 43334-42. doi:10.1074/jbc.M104994200. PMID 11562359.
Suzuki Y, Imai Y, Nakayama H, et al. (2001). "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.". Mol. Cell 8 (3): 613-21. PMID 11583623.
Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.". Nature 416 (6878): 345-7. doi:10.1038/416345a. PMID 11907583.
Gordon GJ, Appasani K, Parcells JP, et al. (2002). "Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma.". Carcinogenesis 23 (6): 1017-24. PMID 12082024.
Sharief MK, Noori MA, Zoukos Y (2002). "Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy.". J. Neuroimmunol. 129 (1-2): 224-31. PMID 12161039.
Ekedahl J, Joseph B, Grigoriev MY, et al. (2002). "Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.". Exp. Cell Res. 279 (2): 277-90. PMID 12243753.