B4GALNT2

From Wikipedia, the free encyclopedia

Beta-1,4-N-acetyl-galactosaminyl transferase 2

Identifiers

B4GALNT2; SD; B4GALGT2; B4GALT; Cad; GALGT2; MGC142235; MGC142237; Sda

External IDs

OMIM: 111730 MGI: 1342058 HomoloGene: 7329

Gene ontology
Molecular Function:	• transferase activity, transferring hexosyl groups
Cellular Component:	• membrane • integral to membrane • integral to Golgi membrane
Biological Process:	• lipid glycosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_153446 (mRNA)
NP_703147 (protein)

NM_008081 (mRNA)
NP_032107 (protein)

Location

Chr 17: 44.57 - 44.6 Mb

Chr 11: 95.68 - 95.73 Mb

Pubmed search

[1]

[2]

Beta-1,4-N-acetyl-galactosaminyl transferase 2, also known as B4GALNT2, is a human gene.^[1]

[edit] References

^ Entrez Gene: B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2.

[edit] Further reading

Berger EG (2002). "Ectopic localizations of Golgi glycosyltransferases.". Glycobiology 12 (2): 29R-36R. PMID 11886838.
Wang HR, Hsieh CY, Twu YC, Yu LC (2008). "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status.". Glycobiology 18 (1): 104-13. doi:10.1093/glycob/cwm120. PMID 17965433.
Kawamura YI, Kawashima R, Fukunaga R, et al. (2005). "Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis.". Cancer Res. 65 (14): 6220-7. doi:10.1158/0008-5472.CAN-05-0639. PMID 16024623.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lo Presti L, Cabuy E, Chiricolo M, Dall'Olio F (2004). "Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain.". J. Biochem. 134 (5): 675-82. PMID 14688233.
Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A (2003). "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.". Biochem. J. 373 (Pt 2): 369-79. doi:10.1042/BJ20021892. PMID 12678917.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dohi T, Yuyama Y, Natori Y, et al. (1996). "Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer.". Int. J. Cancer 67 (5): 626-31. doi:10.1002/(SICI)1097-0215(19960904)67:5<626::AID-IJC6>3.0.CO;2-W. PMID 8782649.
Piller F, Blanchard D, Huet M, Cartron JP (1986). "Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney.". Carbohydr. Res. 149 (1): 171-84. PMID 2425965.