B3GNT3

From Wikipedia, the free encyclopedia

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Identifiers

B3GNT3; B3GAL-T8; B3GN-T3; B3GNT-3; HP10328; TMEM3; beta3Gn-T3

External IDs

OMIM: 605863 MGI: 2152535 HomoloGene: 8602

Gene ontology
Molecular Function:	• galactosyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein amino acid glycosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014256 (mRNA)
NP_055071 (protein)

NM_028189 (mRNA)
NP_082465 (protein)

Location

Chr 19: 17.77 - 17.78 Mb

Chr 8: 74.62 - 74.63 Mb

Pubmed search

[1]

[2]

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, also known as B3GNT3, is a human gene.^[1]

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking.^[1]

[edit] References

^ ^a ^b Entrez Gene: B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3.

[edit] Further reading

Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.". Biochim. Biophys. Acta 1473 (1): 35-53. PMID 10580128.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yeh JC, Hiraoka N, Petryniak B, et al. (2001). "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.". Cell 105 (7): 957-69. PMID 11439191.
Shiraishi N, Natsume A, Togayachi A, et al. (2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.". J. Biol. Chem. 276 (5): 3498-507. doi:10.1074/jbc.M004800200. PMID 11042166.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank.". Gene 228 (1-2): 161-7. PMID 10072769.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.